101583-63-5

Basic information

• Product Name: 2-(2-phenylethyl)-1,2,3,4-tetrahydroquinoline
• Synonyms: 2-(2-phenylethyl)-1,2,3,4-tetrahydroquinoline
• CAS NO: 101583-63-5
• Molecular Weight: 237.345
• Mol File: 101583-63-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(2-phenylethyl)-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylethyl)-1,2,3,4-tetrahydroquinoline(101583-63-5)
• EPA Substance Registry System: 2-(2-phenylethyl)-1,2,3,4-tetrahydroquinoline(101583-63-5)

Safety Data

• Hazardous Substances Data: 101583-63-5(Hazardous Substances Data)

Upstream product

• 91-63-4 2-methylquinoline 
• 1780-19-4 1,2,3,4-tetrahydro-2-methylquinoline 
• 53931-59-2 5-phenyl-1-penten-3-one 
• 100-42-5 styrene 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 38101-69-8 2-[(E)-styryl]quinoline 
• 2785-29-7 benzyl potassium 
• 4945-26-0 2-styrylquinoline 
• 1613-41-8 2-phenethyl-quinoline 

Relevant articles and documents

Heterogeneous gold-catalyzed selective reductive transformation of quinolines with formic acid

Single phase rutile titania supported gold nanoparticles (Au/TiO2-R) are found to be efficient and versatile catalysts for chemo- and regioselective transfer hydrogenation of quinoline derivatives to 1,2,3,4-tetrahydroquinolines (THQs) using formic acid (FA) as a safe and convenient hydrogen source under mild conditions. The activity and chemoselectivity of the Au/TiO2-R catalyst towards THQs is excellent, with a substrate to catalyst ratio (S/C) of 1000 being feasible. Furthermore, a straightforward and selective route to N-formyltetrahydroquinolines (FTHQ) directly from quinoline compounds and FA by one-pot, gold-catalyzed reductive N-formylation protocol is also established.

An efficient catalytic system for the hydrogenation of quinolines

A new catalytic system ([Ru(p-cymene)Cl2]2/I2) has been developed for the hydrogenation of quinoline derivatives with high reactivity. For the 2-methyl-quinoline, the hydrogenation reaction can proceed smoothly at an S/C of 20,000/1 with complete conversion. The iodine additive is important for the reactivity.

Nickel-Catalyzed Dehydrogenation of N-Heterocycles Using Molecular Oxygen

Herein, an efficient and selective nickel-catalyzed dehydrogenation of five- and six-membered N-heterocycles is presented. The transformation occurs in the presence of alkyl, alkoxy, chloro, free hydroxyl and primary amine, internal and terminal olefin, trifluoromethyl, and ester functional groups. Synthesis of an important ligand and the antimalarial drug quinine is demonstrated. Mechanistic studies revealed that the cyclic imine serves as the key intermediate for this stepwise transformation.

Method for conducting catalytic hydrogenation on nitrogen-containing unsaturated heterocyclic compound

The invention provides a method for conducting catalytic hydrogenation on a nitrogen-containing unsaturated heterocyclic compound, and belongs to the technical field of catalytic hydrogenation. The provided method for conducting catalytic hydrogenation on the nitrogen-containing unsaturated heterocyclic compound comprises the following step: in the presence of hydrogen and a manganese catalyst, with the nitrogen-containing unsaturated heterocyclic compound as a substrate, carrying out a hydrogenation reaction. According to the method for conducting catalytic hydrogenation on the nitrogen-containing unsaturated heterocyclic compound, he adopted manganese catalyst is an NNP-type pincer manganese catalyst, has the advantages of being cheap, easy to obtain and low in toxicity compared with noble metal catalysts, has the advantages of being wide in substrate applicability and high in target product yield compared with an existing cheap metal iron catalyst or cobalt catalyst, and is higher in electron donating ability and smaller in steric hindrance compared with a PNP-type pincer manganese catalyst, and thus shows higher reaction activity in a series of hydrogenation reactions, and thetarget product yield is up to 99%.