1016544-71-0

Basic information

• Product Name: (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol
• Synonyms: (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol
• CAS NO: 1016544-71-0
• Molecular Weight: 371.203
• Mol File: 1016544-71-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol(1016544-71-0)
• EPA Substance Registry System: (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanol(1016544-71-0)

Safety Data

• Hazardous Substances Data: 1016544-71-0(Hazardous Substances Data)

Upstream product

• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Downstream Products

• 1016544-26-5 (4-bromo-2-fluorophenyl)(3,4,5-trimethoxyphenyl)methanone 

Relevant articles and documents

Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors

Tubulin polymerization inhibitors had emerged as one of promising anticancer therapeutics because of their dual mechanism of action, i.e. apoptosis by cell-cycle arrest and VDA, vascular disrupting agent. VDAs are believed to be more efficient, less toxic

BENZOPHENONE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE

Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.