57848-46-1 Usage
Description
4-Bromo-2-fluorobenzaldehyde is an organic compound characterized by its light yellow to beige crystalline appearance. It features a benzene ring with a bromine atom at the 4th position and a fluorine atom at the 2nd position, attached to an aldehyde group. 4-Bromo-2-fluorobenzaldehyde is known for its chemical reactivity and is utilized in various synthetic applications.
Uses
Used in Pharmaceutical Synthesis:
4-Bromo-2-fluorobenzaldehyde is used as a key intermediate in the synthesis of nigeglanine hydrobromide, a compound with potential pharmaceutical applications. Its unique structure allows for the creation of complex molecules that can be further developed for therapeutic use.
Used in Chemical Research:
4-Bromo-2-fluorobenzaldehyde serves as a starting material for the preparation of various 2-functionalized aromatic monoaldehydes. By reacting with different secondary amines, it can be used to synthesize a range of chemical products with diverse applications in research and development.
Used in the Development of Novel Antagonists:
4-Bromo-2-fluorobenzaldehyde is employed in the synthesis of phenolfluorostilbenes, which are benzyl amine-based histamine H3 antagonists with serotonin reuptake activity. These compounds have potential applications in the treatment of various neurological and psychiatric disorders.
Used in the Synthesis of Chromone Derivatives:
4-Bromo-2-fluorobenzaldehyde is also utilized in the preparation of 6-bromo-2-(4-bromo-2-fluorophenyl)-2,3-dihydro-4H-chromen-4-one, a chromone derivative with potential applications in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 57848-46-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,8,4 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57848-46:
(7*5)+(6*7)+(5*8)+(4*4)+(3*8)+(2*4)+(1*6)=171
171 % 10 = 1
So 57848-46-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H
57848-46-1Relevant articles and documents
Synthesis and Transformations of Functionalized Benzosiloxaboroles
Czub, Maja,Durka, Krzysztof,Luliński, Sergiusz,?osiewicz, Justyna,Serwatowski, Janusz,Urban, Mateusz,Wo?niak, Krzysztof
, p. 818 - 826 (2017/02/15)
The synthesis and characterization of a series of fluorinated benzosiloxaboroles bearing synthetically useful formyl and cyano groups is reported. These compounds have been obtained by multistep syntheses starting with simple halogenated benzenes. The general synthetic protocol was based on the generation of ortho-boronated aryldimethylsilanes which undergo dehydrogenative cyclization upon hydrolytic workup due to activation of the Si–H bond by the adjacent boronic group. In some cases the synergy of adjacent boron- and silicon-based functionalities resulted in an unexpected hydrosilylation of the CHO group under mild aqueous conditions. The reduction of a benzosiloxaborole derivative bearing the formyl group at the ortho position with respect to the boron atom resulted in a structural transformation reflecting the higher stability of the carboxaborole heterocycle with respect to its silicon counterpart. Thus, a unique heterocyclic system featuring a central 10-membered ring comprising two borasiloxane linkages was isolated.
PROCESSES FOR PRODUCING 4-BROMO-2-METHOXYBENZALDEHYDE
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Page/Page column 3-4, (2012/02/02)
A new synthesis of 4-bromo-2-methoxybenzaldehyde is reported from 1, 4 dibromo 2- fluorobenzene. First, 2-fluoro-4-bromobenzaldehyde is prepared through metal halogen exchange and formylation with a formyl source at 0 °C. After crystallization, this intermediate is reacted with methanol in the presence of potassium carbonate. Subsequently, 4-bromo-2-methoxybenzaldehyde is crystallized.
HISTONE DEACETYLASE INHIBITORS
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, (2011/04/13)
The disclosure provides compounds of formula I and methods for preparation thereof. The compounds act as inhibitor of histone deacetylase.