101670-65-9Relevant articles and documents
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs
Kai, Hiroyuki,Morioka, Yasuhide,Koriyama, Yuji,Okamoto, Kazuya,Hasegawa, Yasushi,Hattori, Maki,Koike, Katsumi,Chiba, Hiroki,Shinohara, Shunji,Iwamoto, Yuka,Takahashi, Kohji,Tanimoto, Norihiko
body text, p. 6444 - 6447 (2009/09/30)
Structure-activity relationships and efforts to optimize the pharmacokinetic profile of isosteric analogs of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among those examined, compound 25 showed potent affinity for cannabinoid receptor 1 (CB1) and receptor 2 (CB2). This compound displayed oral bioavailability and analgesic activity.