463-71-8 Usage
Description
Thiophosgene is a reddish liquid that serves as a photo degradation product of the agricultural fungicide Folpet (F402000). It has a boiling point of 73.5°C and is characterized by its sharp, choking odor. Thiophosgene is a severe eye irritant and may cause severe skin burns upon contact. It is classified as very toxic by inhalation and skin absorption.
Uses
1. Used in Chemical Synthesis:
Thiophosgene is used as a reagent in the chemical industry for the synthesis of various organic compounds, such as thiocarbamates, thiophosphates, and thiourethanes. Its application in chemical synthesis is due to its ability to react with a wide range of substrates, making it a versatile building block for the creation of different chemical products.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Thiophosgene is used as an intermediate in the production of certain drugs. Its role in this application is attributed to its reactivity with various functional groups, allowing for the formation of diverse pharmaceutical compounds with potential therapeutic properties.
3. Used in Pesticide Formulation:
Thiophosgene is used as a component in the formulation of some pesticides, specifically as a degradation product of the fungicide Folpet (F402000). Its application in this industry is due to its ability to contribute to the overall effectiveness of the pesticide, helping to protect crops from fungal infections.
4. Used in Research and Development:
Thiophosgene is utilized in research and development for the study of its chemical properties and potential applications in various fields. Its use in this context is driven by the need to understand its reactivity, stability, and potential hazards, as well as to explore new ways to harness its properties for beneficial purposes.
Air & Water Reactions
Reacts with water to evolve hydrogen chloride, carbon disulfide, and carbon dioxide. Reaction is slow unless the water is hot.
Reactivity Profile
Thiophosgene is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Liberates hydrogen sulfide upon reaction with acids.
Hazard
Toxic by ingestion and inhalation.
Health Hazard
Inhalation causes irritation of respiratory system and delayed pulmonary edema. Vapor irritates eyes. Liquid burns skin and eyes. Ingestion causes irritation of mouth and stomach.
Safety Profile
Poison by intravenous
route. Moderately toxic by ingestion. A skin,
mucous membrane, and severe eye irritant.
When heated to decomposition it emits very
toxic fumes of Cland SOx. See also
PHOSGENE.
Potential Exposure
Primary irritant (w/o allergic reaction). There is not large-scale production of the chemical in the United States It is used to make other chemicals and in laboratory synthesis.
Shipping
UN2474 Thiophosgene, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard; Inhalation Hazard Zone B. PG 2. STN: 49 232 98.
Incompatibilities
Vapors may form explosive mixture with air. Incompatible with water and alcohols. Reacts with water releasing toxic hydrogen chloride, carbon disulfide, and carbon dioxide. Reaction is slow unless the water is hot. Decomposes above 200℃ to highly flammable carbon bisulfide and carbon tetrachloride. Corrodes metals, rubber and some plastics in the presence of moisture. Thiophosgene is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Liberates hydrogen sulfide upon reaction with acids
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Check Digit Verification of cas no
The CAS Registry Mumber 463-71-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 3 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 463-71:
(5*4)+(4*6)+(3*3)+(2*7)+(1*1)=68
68 % 10 = 8
So 463-71-8 is a valid CAS Registry Number.
InChI:InChI=1/CCl2S/c2-1(3)4
463-71-8Relevant articles and documents
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Helfrich,Reid
, p. 594 (1921)
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PROCESS FOR SYNTHESIS FIPRONIL
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Paragraph 0074, (2013/03/26)
The present disclosure relates to a process for trifluoromethylsulfinyl pyrazole compound of formula I, from a compound of formula III, wherein, R, R1 and R2 represent a group containing halogen group respectively and R3 represents a perhaloalkyl.
3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents
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, (2008/06/13)
There are provided 3-(1,2-benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione compounds of formula I and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione compounds of formula II Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
Veterinary composition containing thionosalicylic acid anilides or salts thereof and methods of using the same
-
, (2008/06/13)
New thionosalicylic acid anilides and salts with bases are provided which have parasiticidal activity in sheep and cattle particularly against adult liver flukes in sheep and cattle and other domestic animals, especially against juvenile liver flukes. The new compounds are produced by the reaction of poly-substituted phenols with substituted aromatic isothiocyanates, the hydrolysis products of oxo-thiono- or dithiono-dihydrobenzoxazines or by the reaction of N-phenyl-salicyl-imide chlorides with thio-compounds. Typical compounds are 3,5-dichloro-4'-bromo-thionosalicylic acid anilide and 2-acetoxy-3,5-dichloro-N-(2'-methyl-4'-chlorophenyl)-thionobenzamide. Novel benzoxazines obtainable from the above anilides are also provided and have similar properties. Typical compounds are 3-(3',5'-bis-trifluoromethyl-phenyl)-6,8-dibromo-2-oxo-4-thiono-dihydrobenzoxazine-(1,3), 3-(3',4'-dichlorophenyl)-6,8-dichloro-2,4-dithiono-dihydrobenzoxazine-(1,3) and 3-(4'-bromophenyl)-6-chloro-8-bromo-2,4-dithiono-dihydrobenzoxazine-(1,3). Methods for preparing a large number of both types of compounds are described. The compounds are administered orally or subcutaneously in doses of 2.5 to 100 mg/kg, preferably 5 to 15 mg/kg, of body weight.