10180-02-6

Basic information

• Product Name: 3-(4-chlorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole
• Synonyms: 1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-1,5-diphenyl-; 3-(4-Chlorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole; 3-(4-Chloro-phenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole
• CAS NO: 10180-02-6
• Molecular Formula: C₂₁H₁₇ClN₂
• Molecular Weight: 332.8261
• Mol File: 10180-02-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 475.1°C at 760 mmHg
• Flash Point: 241.1°C
• Density: 1.18g/cm³
• Vapor Pressure: 3.41E-09mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 3-(4-chlorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole(10180-02-6)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole(10180-02-6)

Safety Data

• Hazardous Substances Data: 10180-02-6(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 956-02-5 4'-chlorochalcone 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 99-91-2 para-chloroacetophenone 
• 100-52-7 benzaldehyde 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 100-42-5 styrene 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 95796-92-2 C₂₂H₁₇Cl₂N₃O₃S 
• 105257-89-4 {4-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl}-(4-nitro-phenyl)-diazene 
• 105257-87-2 {4-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl}-phenyl-diazene 
• 105257-88-3 (4-Chloro-phenyl)-{4-[3-(4-chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-phenyl}-diazene 
• 63367-47-5 1-(4-Nitrophenyl)-3-(4-chlorophenyl)-5-phenyl-2-pyrazoline 
• 27293-95-4 3-(4-chlorophenyl)-1,5-diphenyl-1H-pyrazole 
• 95797-02-7 4-[3-(4-Chloro-phenyl)-5-phenyl-4,5-dihydro-pyrazol-1-yl]-benzamide 
• 1207173-24-7 1-(4'-thiocyanophenyl)-3-(4'-chlorophenyl)-5-phenyl-pyrazoline 

Relevant articles and documents

TfOH mediated intermolecular electrocyclization for the synthesis of pyrazolines and its application in alkaloid synthesis

TfOH mediated easy access to interesting pyrazolines starting from an aldehyde, phenylhydrazine and styrene has been developed. The scope of this synthetic methodology has been explored by synthesizing various 1,3,5-trisubstituted pyrazolines in very good yields with very high regioselectivity. The origin of regioselectivity has been explained by comparing the stability of possible intermediate carbocations. The synthetic utility of a green solvent has been explored by synthesizing some of pyrazolines in a DES medium. The synthetic application of the present methodology is employed in the synthesis of a pyrazoline alkaloid.

Synthesis of 1, 3, 5-trisubstituted-4,5-dihydro-1H-pyrazole catalyzed by vitamin B1 and its fluorescence properties

Abstract: An efficient synthesis of 1,3,5-trisubstituted-1H-pyrazoles was developed via cyclocondensation in 78–92% yields starting from α,β-unsaturated aldehydes/ketones with substituted phenylhydrazine using vitamin B1 as a catalyst, and was

Spectroscopic studies of aryl substituted 1-phenyl-2-pyrazolines: Steric and electronic substitution effects

A series of aryl substituted 1-phenyl-2-pyrazolines containing electron-donating and electron-withdrawing substituents on different positions of the C3– or C5-aryl groups were synthesized and their steric and electronic effects on ch