1018987-52-4

Basic information

• Product Name: 3-[4-(2-furyl)phenyl]-2-propyn-1-ol
• Synonyms: 3-[4-(2-furyl)phenyl]-2-propyn-1-ol
• CAS NO: 1018987-52-4
• Molecular Weight: 198.221
• Mol File: 1018987-52-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-[4-(2-furyl)phenyl]-2-propyn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2-furyl)phenyl]-2-propyn-1-ol(1018987-52-4)
• EPA Substance Registry System: 3-[4-(2-furyl)phenyl]-2-propyn-1-ol(1018987-52-4)

Safety Data

• Hazardous Substances Data: 1018987-52-4(Hazardous Substances Data)

Upstream product

• 14297-34-8 2-(p-bromophenyl)furane 
• 107-19-7 propargyl alcohol 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 1018987-62-6 C₁₃H₁₁IO₂ 
• 1152316-52-3 (Z)-3-[4-(2-furyl)phenyl]-2-propen-1-ol 
• 452296-40-1 N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycine 
• 1018987-50-2 methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate 
• 1018987-51-3 methyl N-[(2Z)-3-[4-(2-furyl)phenyl]-3-(3-thienyl)-2-propen-1-yl]-N-methylglycinate oxalate salt 

Relevant articles and documents

Utilization of sequential palladium-catalyzed cross-coupling reactions in the stereospecific synthesis of trisubstituted olefins

A stereospecific synthesis of the drug-candidate 1 is described. The synthetic sequence, aimed at accomplishing modularity and cost savings, features a series of organometallic steps to afford stereospecifically the desired trisubstituded olefin active pharmaceutical ingredient. Key developments consist of a mild Sonogashira reaction of aryl bromide 7a with the polymerization prone propargyl alcohol and a stereospecific hydroalumination, Zn/Al exchange, and Pd-catalyzed cross-coupling sequence facilitated by the commercially available PEPPSI catalyst.