1019217-61-8

Basic information

• Product Name: methyl 4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate
• Synonyms: methyl 4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate
• CAS NO: 1019217-61-8
• Molecular Weight: 761.261
• Mol File: 1019217-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate(1019217-61-8)
• EPA Substance Registry System: methyl 4-(3-{5-chloro-1-(diphenylmethyl)-2-[2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}propyl)benzoate(1019217-61-8)

Safety Data

• Hazardous Substances Data: 1019217-61-8(Hazardous Substances Data)

Upstream product

• 540522-70-1 methyl 4-{3-[2-(2-aminoethyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoate 
• 103008-51-1 2-(trifluoromethoxy)benzenesulfonyl chloride 

Downstream Products

• 1019218-24-6 C₄₀H₃₄ClF₃N₂O₅S 

Relevant articles and documents

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

The synthesis and structure-activity relationship of a series of benzenesulfonamide indole inhibitors of cPLA2α are described. Substitution of the benzenesulfonamide led to analogues with 50-fold improvement in potency versus the unsubstituted benzenesulfonamide lead compound. Rat pharmacokinetics in a minimal formulation was used to prioritize compounds, leading to the discovery of a potent inhibitor of cPLA2α with oral efficacy in models of rat carrageenan paw edema and Ascaris suum airway challenge in naturally sensitized sheep.