101924-89-4

Basic information

• Product Name: tert-butyloxycarbonylglutamic acid α-phenylhydrazide
• Synonyms: tert-butyloxycarbonylglutamic acid α-phenylhydrazide
• CAS NO: 101924-89-4
• Molecular Weight: 337.376
• Mol File: 101924-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyloxycarbonylglutamic acid α-phenylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyloxycarbonylglutamic acid α-phenylhydrazide(101924-89-4)
• EPA Substance Registry System: tert-butyloxycarbonylglutamic acid α-phenylhydrazide(101924-89-4)

Safety Data

• Hazardous Substances Data: 101924-89-4(Hazardous Substances Data)

Upstream product

• 2419-94-5 Boc-Glu 
• 100-63-0 phenylhydrazine 

Downstream Products

• 101924-92-9 tert-butyloxycarbonylglutamic acid α-phenylhydrazide γ-anilide 
• 101924-91-8 tert-butyloxycarbonylglutamic acid α-phenylhydrazide γ-methylamide 
• 101924-90-7 tert-butyloxycarbonylglutamic acid α-phenylhydrazide γ-methylester 

Relevant articles and documents

APPLICABILITY OF GLUTAMINYL-tRNA CYCLOTRANSFERASE IN THE PEPTIDE SYNTHESIS

Peptides with amino-terminal glutamine and their derivatives on treatment with crude papain preparation, containing glutaminyl-tRNA cyclotransferase (E.C. 2.3.2.5.), are converted into the corresponding compounds with pyroglutamic acid.This enzymic cyclization does not take place with glutamic acid or its γ-derivatives.The reaction has been optimized for the preparation of pyroglutamic acid phenylhydrazide.Glutaminyl-leucine phenylhydrazide and glutaminyl-histidyl-proline amide reacted to give pyroglutamyl-leucine phenylhydrazide and TRH, respectively.Treatment of crude papain with iodoacetamide completely inhibited its activity without affecting the glutaminyl-cyclotransferase activity.