1019436-10-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]-;2-methyl-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine
• CAS NO: 1019436-10-2
• Molecular Formula: C₁₅H₁₄N₂O₂S
• Molecular Weight: 286.34886
• Mol File: 1019436-10-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]-(1019436-10-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]-(1019436-10-2)

Safety Data

• Hazardous Substances Data: 1019436-10-2(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]is a chemical compound that features a pyrrolopyridine ring structure with a methyl group and a sulfonyl group attached at specific positions.

Chemical Group

This compound belongs to the pyrrolopyridine group.

Use in Medicinal Chemistry

1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]is often used in medicinal chemistry and pharmaceutical research as a building block or intermediate in the synthesis of pharmaceutical drugs.

Structural Features

This compound is valued for its structural features, including the pyrrolopyridine ring system and the attached methyl and sulfonyl groups.

Potential Pharmaceutical Relevance

The specific properties and potential applications of 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-[(4-methylphenyl)sulfonyl]may vary depending on the context of its use, but it is generally considered to have potential pharmaceutical relevance due to its unique structure and properties.

Upstream product

• 348640-02-8 1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 74-88-4 methyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 271-63-6 7-Azaindole 

Downstream Products

• 23612-48-8 2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 113975-38-5 1,2-dimethylpyrrolo<2,3-b>pyridine 

Relevant articles and documents

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7

The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.