23612-48-8

Basic information

• Product Name: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-;2-METHYL-1H-PYRROLO[2,3-B]-PYRIDINE;2-Methyl-7-azaindole;2-Methyl-7-azaindole ,99%;2-Methyl-7-azaindole ,98.5%;2-Methyl-7-azaindole, 98.5%, 98.5%
• CAS NO: 23612-48-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Product Categories: Azaindoles
• Mol File: 23612-48-8.mol
• Article Data: 19

Chemical Properties

• Melting Point: 136-142℃
• Appearance: /
• Density: 1.17
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.45±0.40(Predicted)
• CAS DataBase Reference: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(23612-48-8)
• EPA Substance Registry System: 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-(23612-48-8)

Safety Data

• Hazardous Substances Data: 23612-48-8(Hazardous Substances Data)

Usage

Description

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-, also known as 2-Methyl-7-Azaindole, is a white powder chemical compound belonging to the pyrrolo[2,3-b]pyridine family. It is characterized by its unique chemical structure and properties, which make it suitable for various applications in different industries.

Uses

Used in Tobacco Industry:
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYLis used as a chemical marker for fingerprinting the volatile profile of traditional tobacco and e-cigarettes. This application helps in identifying and analyzing the composition of these products, which is crucial for quality control, safety, and regulatory purposes.
Chemical Properties:
The compound is a white powder, which indicates its solid state and potential for easy handling and storage. Its chemical properties, such as stability and reactivity, may also play a role in its suitability for specific applications.

InChI:InChI=1/C8H8N2/c1-6-5-7-3-2-4-9-8(7)10-6/h2-5H,1H3,(H,9,10)

Upstream product

• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 113975-34-1 2,2-dimethyl-N-<3-(2-oxopropyl)-2-pyridinyl>propanamide 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 138343-75-6 tert-butyl (3-methylpyridin-2-yl)carbamate 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 113975-31-8 N-(3-iodopyridin-2-yl)-2,2-dimethylpropionamide 
• 563-83-7 ISOPROPYLAMIDE 
• 42770-24-1 2-methyl-3-methylsulfanyl-1H-pyrrolo[2,3-b]pyridine 
• 1019436-10-2 2-methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 189089-83-6 1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 67-64-1 acetone 

Downstream Products

• 7546-38-5 2-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine 
• 858275-30-6 2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 23616-65-1 2-methyl-3-morpholin-4-ylmethyl-1H-pyrrolo[2,3-b]pyridine 
• 114570-17-1 ethyl 2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-oxoacetate 
• 114570-13-7 (2-Methyl-pyrrolo[2,3-b]pyridin-1-yl)-oxo-acetic acid ethyl ester 
• 189089-83-6 1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 936243-22-0 2-methyl-3-nitroso-1H-pyrrolo[2,3-b]pyridine 
• 936243-62-8 N,N'-bis-Boc-N''-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)guanidine 
• 936243-44-6 2-methyl-1H-pyrrolo[2,3-b]pyridin-3-ylamine 
• 307951-26-4 3-bromo-2-bromomethylpyrrolo[2,3-b]pyridine-1-carboxylic acid methyl ester 
• 307951-35-5 5-bromopyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-3-carboxylic acid methyl ester 
• 307951-54-8 3-bromo-2-bromomethyl-1-phenylsulfonylpyrrolo[2,3-b]pyridine 
• 114570-20-6 2-Hydroxy-1-(2-methyl-pyrrolo[2,3-b]pyridin-1-yl)-2,2-diphenyl-ethanone 

Relevant articles and documents

PREPARATION OF 2-[2-METHYL-1-[[4-METHYLSULFONYL-2-(TRIFLUORO METHYL)PHENYL]METHYL] PYRROLO[2,3-B]PYRIDIN-3-YL]ACETIC ACID

The present invention relates to a novel compound of Formula IV and use of said compound for the preparation of 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl] methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid [fevipiprant], Formula IV wherein A is SO2Me, halogen or a leaving group. The present invention further relates to a process of preparation of pharmaceutical acceptable salts of fevipiprant and composition thereof.

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.