1019453-85-0

Basic information

• Product Name: 2-((2,4-DiMethylphenyl)thio)phenylaMine
• Synonyms: 2-((2,4-DiMethylphenyl)thio)phenylaMine;2-[(2,4-diMethylphenyl)thio]-BenzenaMine;2-((2,4-dimethylphenyl)thio)aniline
• CAS NO: 1019453-85-0
• Molecular Formula: C₁₄H₁₅NS
• Molecular Weight: 229.3406
• EINECS: -0
• Mol File: 1019453-85-0.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 341.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.12±0.10(Predicted)
• CAS DataBase Reference: 2-((2,4-DiMethylphenyl)thio)phenylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2,4-DiMethylphenyl)thio)phenylaMine(1019453-85-0)
• EPA Substance Registry System: 2-((2,4-DiMethylphenyl)thio)phenylaMine(1019453-85-0)

Safety Data

• Hazardous Substances Data: 1019453-85-0(Hazardous Substances Data)

Usage

Description

2-((2,4-DiMethylphenyl)thio)phenylaMine is an organic compound characterized by the presence of a di-methylphenyl group connected to a thioether linkage with an aniline moiety. 2-((2,4-DiMethylphenyl)thio)phenylaMine is known for its unique chemical structure and potential applications in various fields.

Uses

Used in Pharmaceutical Research:
2-((2,4-DiMethylphenyl)thio)phenylaMine is used as a research compound for studying N-O-glucuronide metabolites of Lu AA21004 (Vortioxetine [V766000]), an antidepressant medication. Its involvement in this research is crucial for understanding the metabolic pathways and potential drug interactions of Vortioxetine, contributing to the development of safer and more effective treatments for depression.

Upstream product

• 1610527-49-5 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene 
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• 1425794-19-9 2-(2,4-dimethylphenylsulfanyl)phenyl carbamic acid tert-butyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 
• 137-07-5 2-amino-benzenethiol 
• 4875-10-9 o-nitrothiophenol 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 577-19-5 2-nitrophenyl bromide 
• 95-68-1 2,4-Xylidine 
• 89816-81-9 2,4-dimethylphenyl ethyl xanthate 

Downstream Products

• 4212-74-2 2,4-dimethylphenyl phenyl sulfone 
• 110348-44-2 2,4-dimethylbenzothiophene 5,5-dioxide 
• 1393733-77-1 (2S,3S,4S,5R,6S)-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid 
• 960203-27-4 Vortioxetine hydrobromide 
• 1393644-67-1 4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol 
• 1425794-21-3 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine 
• 1425794-23-5 4-(2-(2,4-dimethylphenylthio)phenyl)-1-methylthiomorpholin-1-ium tetrafluoroborate 
• 1425794-20-2 4-(2-(2,4-dimethylphenylthio)phenyl)thiomorpholine-3,5-dione 
• 960203-28-5 Vortioxetine hydrochloride 
• 508233-74-7 vortioxetine 

Relevant articles and documents

Heterogeneous Iron-Catalyzed Hydrogenation of Nitroarenes under Water-Gas Shift Reaction Conditions

Reduction of various nitroarenes in the presence of heterogeneous iron oxide-based catalyst Fe 2 O 3 /NGr@C under water-gas shift reaction (WGSR) conditions has been demonstrated. The catalytic material is prepared in a straightforward manner via deposition/pyrolysis of iron-phenanthroline complex on carbon support. It shows high chemoselectivity towards the reduction of nitroarenes in the presence of other reducible and/or poisoning-capable functional groups. Hydrogenation is achieved using CO/H 2 O as a hydrogen source. Furthermore, it is demonstrated that the presence of triethylamine additive has a significant positive effect on the rate of reduction.

Manufacturing method of vortioxetine hydrobromide

Is a process for preparing fluoxetine hydrobromide used as an antidepressant. Provided is 1 [(2 dimethylphenyl) sulfanyl] aniline represented by chemical formula 4 - and bis (-chloroethyl) amine hydrochloride and hydrobromic acid represented by the following chemical formula - 2 - are reacted with benzothiazole represented 2,4- by the following general formula 4 or 3 and 2 - 2- [(2,4-dimethylphenyl) sulfanyl] aniline. The method according to claim 6, wherein the thioxanthine hydrobromide is represented by the following formula. Chemical Formula 1. Chemical Formula 2. Chemical Formula 3. Chemical Formula 4. Chemical Formula 6.

Coupling of thiols and aromatic halides promoted by diboron derived super electron donors

We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.