1020153-63-2 Usage
Description
1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is a chemical compound that features a benzene ring with a fluorine atom at the 2nd position and a bromine atom connected to the benzene ring through a three-carbon chain, which includes a triple bond between the first and second carbon atoms. 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is known for its applications in various industries due to its unique structural properties.
Uses
Used in Organic Synthesis:
1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is used as a key intermediate in organic synthesis for the creation of various complex molecules. Its unique structure allows for versatile reactions and functional group manipulations, making it a valuable component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is used as a building block for the development of new drugs. Its structural diversity and reactivity contribute to the design and synthesis of novel therapeutic agents with potential applications in treating various medical conditions.
Used in Agrochemicals:
1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is also utilized in the agrochemical sector as a starting material for the synthesis of pesticides and other agricultural chemicals. Its properties enable the creation of compounds that can effectively control pests and diseases in the agricultural industry.
Used in Material Science:
In the field of material science, 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene is employed in the development of new materials with specific properties. Its incorporation into polymers and other materials can lead to enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Safety Precautions:
It is crucial to handle 1-(3-bromoprop-1-yn-1-yl)-2-fluorobenzene with care, as it is both flammable and potentially hazardous if not managed properly. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, should be taken to minimize risks during its use and storage.
Check Digit Verification of cas no
The CAS Registry Mumber 1020153-63-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,0,1,5 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1020153-63:
(9*1)+(8*0)+(7*2)+(6*0)+(5*1)+(4*5)+(3*3)+(2*6)+(1*3)=72
72 % 10 = 2
So 1020153-63-2 is a valid CAS Registry Number.
1020153-63-2Relevant articles and documents
Tricyclic Triazoles as σ1Receptor Antagonists for Treating Pain
Díaz, José Luis,Cuevas, Félix,Oliva, Ana I.,Font, Daniel,Sarmentero, M. ángeles,álvarez-Bercedo, Paula,López-Valbuena, José M.,Pericàs, Miquel A.,Enrech, Raquel,Montero, Ana,Yeste, Sandra,Vidal-Torres, Alba,álvarez, Inés,Pérez, Pilar,Cendán, Cruz Miguel,Cobos, Enrique J.,Vela, José Miguel,Almansa, Carmen
, p. 5157 - 5170 (2021/05/07)
The synthesis and pharmacological activity of a new series of 5a,7,8,8a-tetrahydro-4H,6H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine derivatives as potent sigma-1 receptor (σ1R) ligands are reported. A lead optimization program aimed at improving the aqueous solubility of parent racemic nonpolar derivatives led to the identification of several σ1R antagonists with a good absorption, distribution, metabolism, and excretion in vitro profile, no off-target affinities, and characterized by a low basic pKa (around 5) that correlates with high exposure levels in rodents. Two compounds displaying a differential brain-to-plasma ratio distribution profile, 12lR and 12qS, exhibited a good analgesic profile and were selected as preclinical candidates for the treatment of pain.
Synthesis of Carbolines via Palladium/Carboxylic Acid Joint Catalysis
Cera, Gianpiero,Lanzi, Matteo,Balestri, Davide,Della Ca, Nicola,Maggi, Raimondo,Bigi, Franca,Malacria, Max,Maestri, Giovanni
supporting information, p. 3220 - 3224 (2018/06/11)
The combination of a Pd(0) complex with benzoic acid converts propargylic tryptamines to the corresponding tetrahydro-β-carbolines. The method uses unprotected indoles and affords the desired products with ample functional group tolerance. Detailed modeling studies reveal a close synergy between the organic and metal catalysts, which enables sequential alkyne isomerization, indole C-H activation, and eventual C-C reductive elimination to afford the target heterocycles.
Tricyclic triazolic compounds
-
Page/Page column 20, (2009/07/10)
The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of
