1020717-77-4

Basic information

• Product Name: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride
• Synonyms: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride
• CAS NO: 1020717-77-4
• Molecular Weight: 257.627
• Mol File: 1020717-77-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride(1020717-77-4)
• EPA Substance Registry System: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl chloride(1020717-77-4)

Safety Data

• Hazardous Substances Data: 1020717-77-4(Hazardous Substances Data)

Usage

Chemical class

Triazole derivatives

Functional group

Carbonyl chloride

Structure

1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carbonyl group attached

Potential applications

Synthesis of biologically active compounds, pharmaceutical industry, medicinal chemistry, development of new drugs and therapeutic agents

Handling precautions

Potential reactivity and toxicity, handle with care

Upstream product

• 697-73-4 2,6-difluorobenzyl chloride 
• 869501-51-9 1-(2,6-difluorobenzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester 
• 217448-86-7 methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate 
• 106308-60-5 2-(azidomethyl)-1,3-difluorobenzene 
• 85118-00-9 2,6-Difluorobenzyl bromide 
• 166196-11-8 CGP 47292 

Downstream Products

• 106308-44-5 rufinamide 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

IMPROVED PROCESS FOR THE PREPARATION OF RUFINAMIDE

The invention relates to a novel, industrially viable, cost effective process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof.

Process for the preparation of rufinamide

The invention provides a novel process for the regioselective preparation of a compound of formula (I)