10210-17-0Relevant articles and documents
Cuspidiol: a new monomeric phenyl propanoid
Ishii,Ishikawa,Chen
, p. 4189 - 4192 (1973)
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A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2SO4/B(OMe)3
Zhou, Yuhan,Gao, Guchao,Li, Hui,Qu, Jingping
, p. 3260 - 3263 (2008)
The reduction of hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2SO4/B(OMe)3 is described. Borane is generated by the reaction of NaBH4 with Me2SO4 in THF, which is as efficient as the commercial one. B(OMe)3 has been successfully applied to increase the reactivity and selectivity of this reaction. The optimum ratio of borane/B(OMe)3/acid is studied, and a variety of hydroxyl-substituted aromatic acids are reduced in good yields.
Synthesis and antiproliferative activity of a new compound containing an α-methylene-γ-lactone group
González, Antonio G.,Silva, Margarita Hernández,Padrón, Juan I.,León, Francisco,Reyes, Eduardo,álvarez-Mon, Melchor,Pivel, Juan P.,Quintana, José,Estévez, Francisco,Bermejo, Jaime
, p. 2358 - 2361 (2002)
The biological activity of compound 9 obtained by introducing an α-methylene-γ-butyrolactone group into 3-(4-hydroxyphenyl)propionic acid, 1, was studied for possible effects on HL-60 cells, murine splenocytes, and human peripheral mononuclear cells (PBMC). 9 induced apoptosis in the HL-60 cell line and has a clear capacity to inhibit proliferation induced in murine splenocytes and PBMC by different mitogenic agents with no apparent toxic side effects. 9 was synthesized from 1, and its structure and stereochemistry were elucidated by spectroscopic methods.
DITERPENES FROM BACCHARIS SPECIES
Bohlmann, Ferdinand,Kramp, Wolfgang,Grenz, Michael,Robinson, Harold,King, Robert M.
, p. 1907 - 1914 (1981)
The investigation of ten Baccharis species afforded in addition to known compounds eight new diterpenes, four ent-labdanes, three kaurenes and a clerodane derivative.Furthermore, two new p-hydroxyacetophenones, a flavone, 3'-methoxyxanthomicrol and two matricaria ester derivatives were isolated.The structures were elucidated by spectroscopic methods and a few chemical transformations.The chemotaxonomic situation of the large genus is discussed briefly. - Keywords: Baccharis species; Compositae; diterpenes; ent-labdanes; clerodane; ent-kauranes; p-hydroxyacetophenone derivatives; acetylenes; flavone; 3'-methoxyxanthomicrol.
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Pearl
, p. 736,738 (1959)
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Scope and limitations of biocatalytic carbonyl reduction with white-rot fungi
Zhuk, Tatyana S.,Skorobohatko, Oleksandra S.,Albuquerque, Wendell,Zorn, Holger
supporting information, (2021/02/02)
The reductive activity of various basidiomycetous fungi towards carbonyl compounds was screened on an analytical level. Some strains displayed high reductive activities toward aromatic carbonyls and aliphatic ketones. Utilizing growing whole-cell cultures of Dichomitus albidofuscus, the reactions were up-scaled to a preparative level in an aqueous system. The reactions showed excellent selectivities and gave the respective alcohols in high yields. Carboxylic acids were also reduced to aldehydes and alcohols under the same conditions. In particular, benzoic, vanillic, ferulic, and p-coumaric acid were reduced to benzyl alcohol, vanillin, dihydroconiferyl alcohol and 1-hydroxy-3-(4-hydroxyphenyl)propan, respectively.
CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE
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Paragraph 0241, (2019/11/11)
The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.