99103-80-7Relevant articles and documents
Heterobivalent Ligand for the Adenosine A2A-Dopamine D2Receptor Heteromer
Casajuana-Martin, Nil,Pardo, Leonardo,Pulido, Daniel,Royo, Miriam,Casadó, Vicent,Casadó-Anguera, Verònica,Ferré, Sergi,Gómez-Autet, Marc,Llopart, Natàlia,Moreno, Estefanía
supporting information, (2022/01/20)
A G protein-coupled receptor heteromer that fulfills the established criteria for its existence in vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors. Here, we have designed and synthesized heterobivalent ligands for the A2AR
A singlet oxygen approach to oxaspirocycles
Jones, Kevin M.,Hillringhaus, Tim,Klussmann, Martin
supporting information, p. 3294 - 3297 (2013/06/27)
A method for the preparation of oxygen containing spirocycles using singlet oxygen is reported. A series of phenols were converted into the corresponding peroxy-cyclohexadienone derivatives by irradiation with visible light in the presence of a sensitizer and oxygen. The resulting peroxides could be converted into ether and lactone spirocycles in one or two steps. The synthesis of the oxaspirocycles from the phenols can also be performed in a one-pot fashion, avoiding the isolation of the peroxide intermediates.
Interaction of functionally-substituted 4-alkyl-2,6-di-tert-butylphenols with hydrohalic acids
Prosenko,Skorobogatov,Dyubchenko,Pinko,Kandalintseva,Shakirov,Pokrovsky
, p. 1119 - 1124 (2008/09/18)
Reactions of 4-alkyl-2,6-di-tert-butylphenols containing OH, SH, COOH, and COOMe groups in their para substituents with hydrogen chloride and hydrohalic acids were studied. One-step transformations of 2,6-di-tert-butyl-4-(ω- hydroxyalkyl)phenols to the corresponding 4-(ω-halogenoalkyl)phenols, as well as of 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid and its esters to phloretic acid were proposed. 4-(3-Mercaptopropyl)phenol upon heating with conc. HBr undergoes condensation to 3-(4-hydroxyphenyl)propyl 4-(3-mercaptopropyl)phenyl sulfide as the main product.
