102169-52-8

Basic information

• Product Name: 2-HYDRAZINOCARBONYL-BENZENESULFONAMIDE
• Synonyms: benzoic acid, 2-(aminosulfonyl)-, hydrazide;2-(aminocarbamoyl)benzenesulfonamide;2-(hydrazinecarbonyl)benzenesulfonamide;2-carbazoylbenzenesulfonamide
• CAS NO: 102169-52-8
• Molecular Formula: C₇H₉N₃O₃S
• Molecular Weight: 215.23208
• Mol File: 102169-52-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 182 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.475g/cm³
• Refractive Index: 1.619
• PKA: 9.73±0.60(Predicted)
• CAS DataBase Reference: 2-HYDRAZINOCARBONYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDRAZINOCARBONYL-BENZENESULFONAMIDE(102169-52-8)
• EPA Substance Registry System: 2-HYDRAZINOCARBONYL-BENZENESULFONAMIDE(102169-52-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 102169-52-8(Hazardous Substances Data)

Usage

General Description

2-Hydrazinocarbonyl-benzenesulfonamide is a chemical compound with the molecular formula C7H9N3O4S. It is a hydrazine derivative and a sulfonamide, with potential applications in medicinal chemistry and pharmaceuticals. 2-HYDRAZINOCARBONYL-BENZENESULFONAMIDE is synthesized as a white to off-white solid, and it is soluble in organic solvents such as dimethyl sulfoxide and dimethyl formamide. Researchers have investigated its potential as a carbonic anhydrase inhibitor, which could make it useful for treating conditions such as glaucoma, epilepsy, and altitude sickness. Additionally, 2-hydrazinocarbonyl-benzenesulfonamide has also been explored for its potential anti-cancer properties. As with any chemical compound, proper handling and precautions should be followed when working with 2-hydrazinocarbonyl-benzenesulfonamide to ensure safety.

InChI:InChI=1/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)

Upstream product

• 81-07-2 saccharin 
• 57683-71-3 methyl 2-(aminosulfonyl)benzoate 

Downstream Products

• 808766-62-3 2-sulfamoyl-benzoyl azide 
• 13338-00-6 2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide 
• 1093390-96-5 2-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)benzenesulfonamide 

Relevant articles and documents

Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties

Targeting proteins overexpressed in hypoxic tumors is as an important means of controlling cancer disease. One such protein is the carbonic anhydrase (CA) isoenzyme IX, which in some types of tumors is overexpressed 150-200-fold. We report here a series of sulfonamide derivatives, prepared from 2-carbohydrazido- and 4-carbohydrazido-benzenesulfonamides, which were further derivatized by reaction with aryl isocyanates or arylsulfonyl isocyanates. Several low nanomolar CA IX inhibitors were detected in this way. SAR is discussed for the diverse types of inhibitors and their affinity for different isozymes, with the aim of obtaining isozyme-specific CA IX inhibitors, with putative applications as antitumor drugs.

Microwave synthesis, crystal structure and spectroscopic investigations of 2-{[(2E)-(2-chlorobenzylidene) hydrazine] carbonyl} benzenesulfonamide and 2-({[(2E)-2-[4-(dimethylamino) benzylidene] hydrazine} carbonyl) benzenesulfonamide

The compounds 2-{[(2E)-(2-chlorobenzylidene) hydrazine] carbonyl} benzenesulfonamide 5a and 2-({[(2E)-2-[4- (dimethylamino)benzylidene] hydrazine} carbonyl) benzenesulfonamide 5b have been synthesized by microwave heating and characterized by NMR, FT-IR a