1021852-90-3

Basic information

• Product Name: H-Tyr-NMe-D-Ala-Phe-NMe-Gly-NH₂
• CAS NO: 1021852-90-3
• Molecular Weight: 483.568
• Mol File: 1021852-90-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-Tyr-NMe-D-Ala-Phe-NMe-Gly-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: H-Tyr-NMe-D-Ala-Phe-NMe-Gly-NH₂(1021852-90-3)
• EPA Substance Registry System: H-Tyr-NMe-D-Ala-Phe-NMe-Gly-NH₂(1021852-90-3)

Safety Data

• Hazardous Substances Data: 1021852-90-3(Hazardous Substances Data)

Upstream product

• 13734-36-6 N-(tert-butoxycarbonyl)sarcosine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 40298-71-3 N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine 
• 13734-31-1 N-tert-butoxycarbonyl-N-methyl-(R)-alanine 

Relevant articles and documents

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: Role of lipophilicity vs structural flexibility

Two dermorphin analogues having an almost identical structure but different structural flexibility were compared for opioid activity. In 1 the aromatic side chains were incorporated into a lactam structure, while in 2 N-amide alkylation was retained but the side chains were flexible. Both compounds produced comparable antinociceptive effects in the mouse tail flick test after peripheral administration. This indicates that lipophilicity, rather than side chain flexibility, is the key determinant for blood-CNS barrier penetration.