1022957-12-5Relevant articles and documents
Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity
Ott, Gregory R.,Tripathy, Rabindranath,Cheng, Mangeng,McHugh, Robert,Anzalone, Andrew V.,Underiner, Ted L.,Curry, Matthew A.,Quail, Matthew R.,Lu, Lihui,Wan, Weihua,Angeles, Thelma S.,Albom, Mark S.,Aimone, Lisa D.,Ator, Mark A.,Ruggeri, Bruce A.,Dorsey, Bruce D.
, p. 493 - 498 (2011/03/19)
A series of novel 7-amino-1,3,4,5-tetrahydrobenzo[b]azepin-2-one derivatives within the diaminopyrimidine class of kinase inhibitors were identified that target anaplastic lymphoma kinase (ALK). These inhibitors are potent against ALK in an isolated enzym