72503-43-6

Basic information

• Product Name: 6-methoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
• Synonyms: 6-methoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one;6-METHOXY-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE
• CAS NO: 72503-43-6
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.22642
• Mol File: 72503-43-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-methoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one(72503-43-6)
• EPA Substance Registry System: 6-methoxy-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one(72503-43-6)

Safety Data

• Hazardous Substances Data: 72503-43-6(Hazardous Substances Data)

Upstream product

• 33892-75-0 5-Methoxy-1-tetralone 
• 30069-58-0 5-methoxy-1-tetralone oxime 
• 30069-58-0 5-methoxy-3,4-dihydro-2H-naphthalen-1-one oxime 

Downstream Products

• 604004-23-1 6-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine 
• 1022957-12-5 C₂₅H₂₉ClN₆O₃ 
• 1485056-59-4 6-(2-fluorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-60-7 6-(3-fluorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-61-8 6-(4-fluorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-62-9 6-(2-chlorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-63-0 6-(3-chlorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-64-1 6-(4-chlorobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-65-2 6-(4-bromobenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-66-3 6-(4-methylbenzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 
• 1485056-67-4 6-(benzyloxy)-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one 

Relevant articles and documents

Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT

A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR (Ki = 43 and 56 nM), whereas compounds 11c and 14a were the most potent analogs at the SERT (Ki = 34 and 17 nM). On the other hand, compounds 14b and 11d showed potent activity at both targets, displaying a profile that makes them promising leads for the search for novel potent ligands with a dual mechanism of action. Molecular docking studies in all the compounds unveiled relevant drug–target interactions, which allowed rationalizing the observed affinities.

2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS

The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

Dynamic and static conformational analysis of acylated tetrahydrobenzazepines

A detailed high-field NMR analysis of several acylated tetrahydrobenzazepines, supported by molecular mechanics calculations, indicates that the heterocyclic ring in these compounds exists in a chair conformation, with the carbonyl oriented anti to the aryl moiety in the dominant rotamer. Surprisingly, ring methylenes are typically diastereotopic at room temperature, as the barriers for the process of enantiomerization of the seven-membered ring are much higher than expected. It is shown that ring inversion is correlated (but not concerted) with rotation of the amide moiety, as the carbonyl is forced out of conjugation with the nitrogen in the transition state.