1022984-10-6

Basic information

• Product Name: C₁₇H₁₅FN₂O₃
• CAS NO: 1022984-10-6
• Molecular Weight: 314.316
• Mol File: 1022984-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₅FN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₅FN₂O₃(1022984-10-6)
• EPA Substance Registry System: C₁₇H₁₅FN₂O₃(1022984-10-6)

Safety Data

• Hazardous Substances Data: 1022984-10-6(Hazardous Substances Data)

Upstream product

• 319-03-9 4-fluorophthalic anhydride 
• 340141-97-1 2-methoxy-N¹,N¹-dimethylbenzene-1,4-diamine 

Relevant articles and documents

Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils

Based on the structural features of Indoprofen and PIB, a series of isoindol-1,3-diones 1a-k and isoindol-1-ones 2a-l were designed and synthesized. These 23 compounds were evaluated by competitive binding assay against aggregated Aβ42 fibrils using [125I]TZDM. All the isoindolone derivatives showed very good binding affinities with Ki values in the subnanomolar range (0.42-0.94 nM). Among them, isoindol-1,3-diones 1i and 1k and isoindol-1-ones 2c and 2i exhibited excellent binding affinities (Ki = 0.42-0.44 and 0.46-0.49 nM) than those of Indoprofen (Ki = 0.52 nM) and PIB (Ki = 0.70 nM). These results suggest that isoindolones could be served as a scaffold for potential AD diagnostic probes to monitor Aβ fibrils.