319-03-9 Usage
Description
5-Fluoro-1,3-isobenzofurandione, also known as 4-fluorophthalic anhydride, is a fluorinated building block that is commonly used in chemical synthesis. It is a white to light yellow crystal powder and can be synthesized by treating 4-chlorophthalic anhydride with potassium fluoride. 5-Fluoro-1,3-isobenzofurandione has a wide range of applications across different industries due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
5-Fluoro-1,3-isobenzofurandione is used as a key building block for the preparation of various compounds, including polyimide, pesticides, herbicides, and fungicides. Its fluorinated structure provides unique properties to the synthesized products, making it a valuable component in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Fluoro-1,3-isobenzofurandione is used as a reactant to prepare 5-fluoro-2-pyridin-3-ylmethyl-isoindole-1,3-dione by reacting with C-pyridin-3-yl-methylamine. 5-Fluoro-1,3-isobenzofurandione has potential applications in the development of new drugs and therapeutic agents.
Used in Fluorescent Probes and Bioactive Compounds:
5-Fluoro-1,3-isobenzofurandione is used as a reactant to prepare 4-amino substituted phthalimides, which are applicable as potential fluorescent probes and fluorescent bioactive compounds. These compounds have significant applications in research and diagnostics, particularly in the field of biochemistry and molecular biology.
Used in Polymer Synthesis:
In the polymer industry, 5-Fluoro-1,3-isobenzofurandione is used as a reactant to prepare 4,4′-bis(4-fluorophthalimido)diphenyl ether monomer. This monomer is then used in the synthesis of cardo polymers via nucleophilic substitution polymerization reaction. The resulting polymers have unique properties and can be used in various applications, such as in the electronics and aerospace industries.
Used in Asymmetric Polyimides:
5-Fluoro-1,3-isobenzofurandione is also used in the synthesis of asymmetric polyimides through a solution polycondensation reaction. These polyimides have specific properties that make them suitable for use in high-performance applications, such as in the production of advanced materials for aerospace, automotive, and electronics industries.
Check Digit Verification of cas no
The CAS Registry Mumber 319-03-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 319-03:
(5*3)+(4*1)+(3*9)+(2*0)+(1*3)=49
49 % 10 = 9
So 319-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H3FO3/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3H
319-03-9Relevant articles and documents
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Ishikawa et al.
, p. 359 (1975)
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COMPOUNDS AND USES THEREOF
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Page/Page column 177-178, (2021/08/06)
The present disclosure features compounds and methods useful for the treatment of BAF complex-related disorders.
Substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof
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Page/Page column 73-74; 93-94, (2020/11/23)
The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.
Synthesis of 4-substituted phthalic anhydrides
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, (2008/06/13)
Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula STR1 The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula STR2 The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula STR3 where R1, R2, and R4 are preferably H and R3 is preferably Cl or F.
