1023971-10-9

Basic information

• Product Name: (-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid
• CAS NO: 1023971-10-9
• Molecular Weight: 179.24
• Mol File: 1023971-10-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid(1023971-10-9)
• EPA Substance Registry System: (-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid(1023971-10-9)

Safety Data

• Hazardous Substances Data: 1023971-10-9(Hazardous Substances Data)

Upstream product

• 921-01-7 D-cysteine 
• 62116-24-9 3-acetoxypropyl iodide 
• 628-09-1 3-Chloropropyl acetate 
• 592-33-6 3-bromopropyl acetate 
• 353-05-9 3-fluoropropyl acetate 
• 627-18-9 1-bromo-3-propanol 
• 52-90-4 L-Cysteine 
• 107-18-6 allyl alcohol 

Downstream Products

• 287407-38-9 2-(4-but-2-ynyloxy-benzenesulfonylamino)-3-(3-hydroxy-propylsulfanyl)-propionic acid tert-butyl ester 
• 287407-39-0 4-(4-but-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid tert-butyl ester 
• 287404-65-3 (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid hydroxyamide 
• 287407-40-3 (S)-4-(4-But-2-ynyloxy-benzenesulfonyl)-[1,4]thiazepane-3-carboxylic acid 

Relevant articles and documents

Preparation method of high-purity fudosteine

The invention discloses a preparation method of high-purity fudosteine, and belongs to the technical field of synthesis of pharmaceutical compounds. The preparation method is characterized in that with 3-halogenated propyl acetate or 3-halogenated propyl propionate and L-cysteine as starting materials, a fudosteine crude product is prepared through a reaction in an aqueous alkali solution, and high-purity fudosteine is obtained by refining the fudosteine crude product. The preparation method has the advantages that the reaction conditions are mild, the reaction process is simple, the yield ishigh, the cost is low, the requirement that the content of unknown impurities is lower than 0.1% can be met, and the preparation method is suitable for industrial application.

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Potent and selective TACE and MMP inhibitors utilizing the diazepine and thiazepine ring systems were synthesized and evaluated for biological activity in in vitro and in vivo models of TNF-α release. Oral activity in the mouse LPS model of TNF-α release