1025-89-4

Basic information

• Product Name: 1H-1,2,4-Triazole, 5-methyl-1,3-diphenyl-
• CAS NO: 1025-89-4
• Molecular Formula: C15H13N3
• Molecular Weight: 235.288
• Mol File: 1025-89-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-1,2,4-Triazole, 5-methyl-1,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole, 5-methyl-1,3-diphenyl-(1025-89-4)
• EPA Substance Registry System: 1H-1,2,4-Triazole, 5-methyl-1,3-diphenyl-(1025-89-4)

Safety Data

• Hazardous Substances Data: 1025-89-4(Hazardous Substances Data)

Usage

Chemical Structure

1H-1,2,4-Triazole, 5-methyl-1,3-diphenyl-

Explanation

This structure consists of a triazole ring (a five-membered ring with three nitrogen atoms and two carbon atoms) with a methyl group (CH3) attached to the 5th position and two phenyl groups (C6H5) attached to the 1st and 3rd positions.

Explanation

The compound is derived from the triazole ring, which is a heterocyclic compound containing three nitrogen atoms.

Explanation

The compound has been studied for its potential to exhibit various biological activities, including fighting fungal infections, inhibiting viral replication, and combating cancer cells.

Explanation

Due to its biological activities, the compound is considered valuable in the field of pharmaceutical research and drug development.

Explanation

The compound has been explored for its possible applications in the agrochemical industry, which involves the development of chemical products for use in agriculture.

Explanation

The compound can be utilized as a starting material or intermediate in the synthesis of more complex organic molecules.

Explanation

The solubility of the compound in various solvents is not specified in the given information.

Explanation

The stability of the compound under different conditions (e.g., temperature, pH, etc.) is not provided in the material.

Explanation

Information about the toxicity of the compound, such as its potential harmful effects on humans or the environment, is not included in the material.

Triazole Derivative

Yes

Biological Activities

Antifungal, antiviral, and anticancer potential

Pharmacological Properties

Potential applications in drug development

Agrochemical Applications

Investigated for potential use

Organic Synthesis

Used as a building block

Solubility

Not mentioned in the material provided

Stability

Not mentioned in the material provided

Toxicity

Not mentioned in the material provided

Upstream product

• 108-24-7 acetic anhydride 
• 46721-85-1 N′-phenylbenzimidohydrazide 
• 231289-36-4 C,N-Diphenylnitrilimine 
• 80-62-6 methacrylic acid methyl ester 
• 298-96-4 triphenyltetrazolium chloride 
• 825-60-5 benzimidic acid ethyl ester 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 588-64-7 benzaldehyde phenylhydrazone 
• 2346-00-1 2-methyl-4,5-dihydro-thiazole 
• 51112-85-7 4-chlorobenzonitrile N-phenylimine 
• 75-05-8 acetonitrile 
• 100-63-0 phenylhydrazine 
• 20205-73-6 N-Acetylbenzimidsaeure-ethylester 
• 114064-53-8 N-[1-(5-Methyl-tetrazol-1-yl)-1-phenyl-meth-(Z)-ylidene]-N'-phenyl-hydrazine 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

Reactions of Nitrile Oxides and Nitrile Imines with Derivatives of 4,5-Dihydrooxazole and 4,5-Dihydrothiazole and with Related Compounds

2-Phenyl-4,5-dihydrooxazole 4 gives a cycloadduct 6 when treated with benzonitrile N-oxide; with a 1-oxoalkene- or α-oxoarene-nitrile N-oxide (RCOCNO), an open chain product, RCO2CH2N(CN)COPh , is obtained.The six-membered-ring analogue of compound 4 undergoes similar reactions.Depending on the nature of the ring substituents, a substituted 4,5-dihydrooxazole reacts with a C,N-diarylnitrile imine, to give either a cycloadduct, e.g. 17, or a 1,2,4-triazol-4-ium salt, e.g. 19.The product from the reaction of 4,5-dihydro-2-methylthiazole 1b with a nitrile imine depends upon the nature of the C- and N-substituents in the latter.In all cases it is postulated that a 4-substituted triazolium salt 24 is formed.This may lose thiirane to give a substituted 1,2,4-triazole 25, or it may react with a second molecule of the precursor of the nitrile imine, to give a 4-substituted 1,2,4-triazolium salt, e.g. 27, in which the precursor moiety is incorporated into the C-4 side chain.

SYNTHESIS AND THERMOLYSIS OF SOME N-HYDROXIMOYL- AND N-HYDRAZONOYLAZOLES

The reactions of nitrile oxides or nitrile imines with pyrazole, imidazole, 1,2,3- and 1,2,4-triazole or tetrazole derivatives yield the appropriate N-hydroximoyl- or N-hydrazonoylazoles.Thermolysis of 1-hydroximoyltetrazoles, depending on the nature of the substituents in the tetrazole ring, yields 1,2,4-oxadiazoles or 5-amino-1,2,4-oxadiazoles upon hydrazoic acid or nitrogen evolution.Under similar conditions, 1-hydrazonoyltetrazoles give 1,2,4-triazoles or 5-amino-1,2,4-triazoles while 2-hydrazonoyltetrazoles decompose to the dihydro-1,2,4,5-tetrazine derivatives.