10252-46-7

Basic information

• Product Name: 1H-Pyrazole, 4,5-dihydro-3-methyl-1-phenyl-
• CAS NO: 10252-46-7
• Molecular Formula: C10H12N2
• Molecular Weight: 160.219
• Mol File: 10252-46-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 4,5-dihydro-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 4,5-dihydro-3-methyl-1-phenyl-(10252-46-7)
• EPA Substance Registry System: 1H-Pyrazole, 4,5-dihydro-3-methyl-1-phenyl-(10252-46-7)

Safety Data

• Hazardous Substances Data: 10252-46-7(Hazardous Substances Data)

Upstream product

• 59-88-1 phenylhydrazine hydrochloride 
• 78-94-4 methyl vinyl ketone 
• 1259475-48-3 Br^(1-)*C₂₈H₂₄N₂P⁽¹⁺⁾ 
• 1259475-46-1 triphenyl[(1-phenyl-4,5-dihydro-1-pyrazol-3-yl)methyl]phosphonium bromide 
• 100-63-0 phenylhydrazine 
• 927-74-2 3-Butyn-1-ol 
• 105486-35-9 N-[1-Methyl-3-tributylstannanyl-prop-(Z)-ylidene]-N'-phenyl-hydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 107-80-2 1,3-dibromobutane 
• 105486-38-2 (1-Methyl-cyclopropyl)-phenyl-diazene 
• 881-05-0 3-Methyl-1-phenyl-2-pyrazoline-4,5-dione 
• 60044-74-8 4-ethoxy-butan-2-one 
• 590-90-9 1-Hydroxy-3-butanone 
• 6322-49-2 4-chloro-2-butanone 

Downstream Products

• 1128-54-7 3-methyl-1-phenyl-1H-pyrazole 

Relevant articles and documents

Additive-free pd-catalyzed α-allylation of imine-containing heterocycles

An additive-free Pd-catalyzed α-allylation of different imino-group-ontaining heterocycles is reported. The activation of α-CH pronucleophiles (pKa (DMSO) > 25) occurs without the addition of strong bases or Lewis acids using only the Pd/Xantphos catalyst system. The reaction scope has been studied for various 5- and 6-membered nitrogen-containing heterocycles (yields up to 96%). Mechanistic investigations suggest an initial allylation of the imine-N followed by a Pd-catalyzed formal aza-Claisen rearrangement.

Unexpected ring opening of pyrazolines with activated alkynes: synthesis of 1H-pyrazole-4,5-dicarboxylates and chromenopyrazolecarboxylates

1H-Pyrazole-4,5-dicarboxylates and chromenopyrazole carboxylates were prepared by reacting pyrazolines with activated alkynes under neat conditions without a catalyst. The products were formed via unexpected ring opening of pyrazolines with the elimination of styrene/ethylene. These types of transformations are unknown and the products formed were confirmed using their spectral/analytical data. In addition, the structures of compounds 5e and 5n were confirmed by single-crystal X-ray analysis. Control experiments were conducted to support the proposed reaction mechanism.

Heterocyclization of β,γ-unsaturated onium compounds of phosphorus and nitrogen under the action of phenylhydrazine

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