102569-26-6

Basic information

• Product Name: 2-aMino-4-hydroxy-3-Methylbenzonitrile
• Synonyms: 2-aMino-4-hydroxy-3-Methylbenzonitrile
• CAS NO: 102569-26-6
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Mol File: 102569-26-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-aMino-4-hydroxy-3-Methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-4-hydroxy-3-Methylbenzonitrile(102569-26-6)
• EPA Substance Registry System: 2-aMino-4-hydroxy-3-Methylbenzonitrile(102569-26-6)

Safety Data

• Hazardous Substances Data: 102569-26-6(Hazardous Substances Data)

Usage

General Description

2-Amino-4-hydroxy-3-methylbenzonitrile is a chemical compound that belongs to the class of benzonitriles. It has a molecular formula C8H8N2O and a molecular weight of 148.16 g/mol. It is known for its role in the synthesis of pharmaceuticals, particularly in the development of various drugs. Additionally, it is utilized in the production of dyes and other organic compounds. The compound is notable for its potential therapeutic applications, and its structure and properties make it a valuable component in medicinal chemistry and drug development.

Upstream product

• 72817-94-8 4-amino-5-cyano-2-hydroxy-3-methylbenzoic acid 
• 72817-85-7 4-Amino-5-cyan-3-methyl-salicylsaeure-ethylester 

Downstream Products

• 923274-68-4 2-amino-4-methoxy-3-methylbenzonitrile 
• 922520-33-0 2-amino-4-methoxy-3-methyl benzamide 
• 922520-32-9 2-amino-4-methoxy-3-methyl-benzoic acid methyl ester 
• 922520-29-4 7-Methoxy-8-methyl-2-phenylquinazolin-4-ol 
• 1202186-95-5 C₁₅H₁₅N₃O₃ 
• 922520-24-9 2-(4-fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-ol 
• 922520-23-8 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid 
• 922520-22-7 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid methyl ester 
• 923275-56-3 2-amino-4-methoxy-3-methyl benzoic acid 
• 923275-17-6 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline 
• 923274-98-0 4-Methoxy-3-methyl-2-[(5-methyl-pyridine-2-carbonyl)-amino]-benzoic acid methyl ester 
• 923274-69-5 4-Isopropylthiazole-2-carboxylic acid (6-carbamoyl-3-methoxy-2-methyl-phenyl)-amide 

Relevant articles and documents

Macrocylic Inhibitors of Hepatitis C Virus

Compounds of the formula I: and N-oxides, salts, and stereoisomers thereof wherein A is OR1, NHS(═O)pR2; wherein; R1 is hydrogen, C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl;R2 is C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl;p is independently 1 or 2;n is 3, 4, 5 or 6; — denotes an optional double bond;L is N or CRz; Rz is H or forms a double bond with the asterisked carbon;Rq is H or when L is CRz, Rq can also be C1-C6alkyl;Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C1-C6 alkyl, C1-C6alkoxy, hydroxyl, halo, haloC1-C6alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C1-C6alkyl-carbonylamino, C0-C3alkylenecarbocyclyl and C0-C3 alkyleneheterocyclyl;R5 is hydrogen, C1-C6alkyl, C1-C6alkoxyC1-C6alkyl or C3-C7cycloalkyl;R6 is hydrogen, C1-C6alkyl, C1-C6alkoxy, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV

Einfache Synthese neuer 2-Amino-4-hydroxybenzonitrile

4-Aminosalicylic acid derivatives are decarboxylated to the 2-amino-4-hydroxybenzonitriles 2 by heating in quinoline at 170-180 deg C.The bromo and iodo derivatives of 2 are prepared by nuclear bromination and reaction with iodine in the presence of iodic