923274-68-4

Basic information

• Product Name: 2-aMino-4-Methoxy-3-Methylbenzonitrile
• Synonyms: 2-aMino-4-Methoxy-3-Methylbenzonitrile
• CAS NO: 923274-68-4
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.1885
• Mol File: 923274-68-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-aMino-4-Methoxy-3-Methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-4-Methoxy-3-Methylbenzonitrile(923274-68-4)
• EPA Substance Registry System: 2-aMino-4-Methoxy-3-Methylbenzonitrile(923274-68-4)

Safety Data

• Hazardous Substances Data: 923274-68-4(Hazardous Substances Data)

Usage

Description

2-Amino-4-Methoxy-3-Methylbenzonitrile is a chemical compound with the molecular formula C9H10N2O. It is a white to light yellow powder that is insoluble in water but soluble in organic solvents. 2-aMino-4-Methoxy-3-Methylbenzonitrile is known for its potential applications in various fields, including pharmaceuticals, dyes, and organic compound synthesis, as well as its role as a building block in the production of chemical products.

Uses

Used in Pharmaceutical Industry:
2-Amino-4-Methoxy-3-Methylbenzonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds. Its unique structural properties make it a valuable component in the creation of various pharmaceutical products.
Used in Dye Industry:
In the dye industry, 2-Amino-4-Methoxy-3-Methylbenzonitrile is used as an intermediate in the production of dyes. Its chemical structure allows it to be a key component in the synthesis of a range of dye products, contributing to their color and performance characteristics.
Used in Organic Compound Synthesis:
2-Amino-4-Methoxy-3-Methylbenzonitrile is utilized as a building block in the synthesis of other organic compounds. Its versatility in chemical reactions makes it a valuable asset in the development of a wide array of organic products.
Used in Medicinal Chemistry and Drug Development:
Due to its structural properties, 2-Amino-4-Methoxy-3-Methylbenzonitrile has potential applications in the field of medicinal chemistry and drug development. Researchers can leverage its unique characteristics to explore new avenues in the creation of pharmaceuticals and therapeutic agents.
It is important to handle 2-Amino-4-Methoxy-3-Methylbenzonitrile with caution, as it may pose health risks if not used properly. Proper safety measures should be taken to ensure the safe use of this compound in various applications.

Upstream product

• 74-88-4 methyl iodide 
• 102569-26-6 2-amino-4-hydroxy-3-methylbenzonitrile 
• 72817-94-8 4-amino-5-cyano-2-hydroxy-3-methylbenzoic acid 

Downstream Products

• 912347-94-5 1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone 
• 922520-33-0 2-amino-4-methoxy-3-methyl benzamide 
• 923275-56-3 2-amino-4-methoxy-3-methyl benzoic acid 
• 922520-32-9 2-amino-4-methoxy-3-methyl-benzoic acid methyl ester 
• 922520-29-4 7-Methoxy-8-methyl-2-phenylquinazolin-4-ol 
• 1202186-95-5 C₁₅H₁₅N₃O₃ 
• 922520-24-9 2-(4-fluoro-phenyl)-7-methoxy-8-methyl-quinazolin-4-ol 
• 922520-23-8 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid 
• 922520-22-7 2-(4-fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid methyl ester 
• 923275-17-6 2-chloro-4-hydroxy-7-methoxy-8-methylquinazoline 
• 923274-98-0 4-Methoxy-3-methyl-2-[(5-methyl-pyridine-2-carbonyl)-amino]-benzoic acid methyl ester 
• 923274-69-5 4-Isopropylthiazole-2-carboxylic acid (6-carbamoyl-3-methoxy-2-methyl-phenyl)-amide 

Relevant articles and documents

Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Novel NS3/4A protease inhibitors comprising quinazoline derivatives as P2 substituent were synthesized. High potency inhibitors displaying advantageous PK properties have been obtained through the optimization of quinazoline P2 substituents in three series exhibiting macrocyclic P2 cyclopentane dicarboxylic acid and P2 proline urea motifs. For the quinazoline moiety it was found that 8-methyl substitution in the P2 cyclopentane dicarboxylic acid series improved on the metabolic stability in human liver microsomes. By comparison, the proline urea series displayed advantageous Caco-2 permeability over the cyclopentane series. Pharmacokinetic properties in vivo were assessed in rat on selected compounds, where excellent exposure and liver-to-plasma ratios were demonstrated for a member of the 14-membered quinazoline substituted P2 proline urea series.

MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is -OR7, -NH-SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents ; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.