1025804-42-5Relevant articles and documents
A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil
Wang, Hui-Po,Lee, On,Fan, Chin-Tsai,Lee, Lain-Tze
, p. 569 - 572 (2007/10/02)
A new synthesis of antihyperlipoproteinemic agent 2,2-dimethyl-5-(2,5-dimethylphenoxy) pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β-lactone 6, prepared from cycloaddition of 3-(2,5-dimethylphenoxy) propanal with dimethylketene.The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industral scale of production.Key Words Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; Dimethylketene; cycloaddition; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone.