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35573-93-4 Usage

Description

3-Chloropropionaldehyde diethylacetal is an acetal compound characterized by its clear colorless to yellow liquid appearance. It is known for its safener activity against thiocarbamate herbicides, making it a valuable additive in the agricultural industry.

Uses

Used in Agriculture:
3-Chloropropionaldehyde diethylacetal is used as a safener for [providing protection against thiocarbamate herbicides] because of its ability to counteract the negative effects of these herbicides on crops, ensuring better crop yield and protection.
Used in Pharmaceutical Synthesis:
3-Chloropropionaldehyde diethylacetal is used as a synthetic intermediate for [various pharmaceutical compounds] due to its versatile chemical properties, which allow it to be a key component in the synthesis of different drugs and therapeutic agents.
In the synthesis of N-[4-[[3-(2, 4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid, an acyclic analog of 5,6,7,8-tetrahydrofolic acid, 3-Chloropropionaldehyde diethylacetal serves as a crucial intermediate for [creating a compound with potential therapeutic applications].
In the synthesis of 1-(D,L)-(3′-amino, 3′-carboxypropyl)uracil, a nucleoamino acid, 3-Chloropropionaldehyde diethylacetal is used as a synthetic building block for [developing novel nucleic acid derivatives with potential applications in medicine and biotechnology].
In the synthesis of 7-methoxychromanone, a compound with potential biological activities, 3-Chloropropionaldehyde diethylacetal is used as a key synthetic intermediate for [creating molecules with potential applications in the pharmaceutical industry].
In the synthesis of grignard reagents, 3-Chloropropionaldehyde diethylacetal is used as a precursor for [producing versatile reagents that can be used in various organic synthesis reactions, including the formation of new carbon-carbon bonds and the synthesis of complex organic molecules].

Check Digit Verification of cas no

The CAS Registry Mumber 35573-93-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,5,7 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 35573-93:
(7*3)+(6*5)+(5*5)+(4*7)+(3*3)+(2*9)+(1*3)=134
134 % 10 = 4
So 35573-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O2.C3H5ClO/c1-4-7-6(3)8-5-2;4-2-1-3-5/h6H,4-5H2,1-3H3;3H,1-2H2

35573-93-4 Well-known Company Product Price

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  • Aldrich

  • (26130)  3-Chloropropionaldehydediethylacetal  technical, ≥90% (GC)

  • 35573-93-4

  • 26130-25ML

  • 983.97CNY

  • Detail
  • Aldrich

  • (26130)  3-Chloropropionaldehydediethylacetal  technical, ≥90% (GC)

  • 35573-93-4

  • 26130-100ML

  • 2,956.59CNY

  • Detail

35573-93-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-chloro-1,1-diethoxypropane

1.2 Other means of identification

Product number -
Other names 3,3-Diethoxypropyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35573-93-4 SDS

35573-93-4Synthetic route

ethanol
64-17-5

ethanol

acrolein
107-02-8

acrolein

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

Conditions
ConditionsYield
With hydrogenchloride; calcium chloride at 0℃; for 24h;90%
With hydrogenchloride
With hydrogenchloride
3-chloropropanaldehyde
19434-65-2

3-chloropropanaldehyde

ethanol
64-17-5

ethanol

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

Conditions
ConditionsYield
With hydrogenchloride at 25℃; Gleichgewicht und Geschwindigkeit der Bildung;
1,3-dichloro-1-ethoxy-propane
89212-07-7

1,3-dichloro-1-ethoxy-propane

ethanol
64-17-5

ethanol

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

1,3-dichloro-1-ethoxy-propane
89212-07-7

1,3-dichloro-1-ethoxy-propane

sodium ethanolate
141-52-6

sodium ethanolate

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

ethanol
64-17-5

ethanol

1,3-dichloro-1-methoxy-propane
4446-86-0

1,3-dichloro-1-methoxy-propane

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

acrolein
107-02-8

acrolein

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

Conditions
ConditionsYield
With hydrogenchloride
With hydrogenchloride; calcium chloride
With hydrogenchloride
hydrogenchloride
7647-01-0

hydrogenchloride

ethanol
64-17-5

ethanol

acrolein
107-02-8

acrolein

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran
141645-16-1

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone
1420181-01-6

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone

Conditions
ConditionsYield
With potassium carbonate; sodium iodide for 6h; Reflux;99%
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

4,4-diethoxy-1-(thiophen-2-yl)butan-1-ol
1258208-43-3

4,4-diethoxy-1-(thiophen-2-yl)butan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: thiophene-2-carbaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
97%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

3,5-dimethylbenzaldehyde
5779-95-3

3,5-dimethylbenzaldehyde

1-(3,5-dimethylphenyl)-4,4-diethoxybutan-1-ol
1258208-42-2

1-(3,5-dimethylphenyl)-4,4-diethoxybutan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: 3,5-dimethylbenzaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
97%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

6,6-diethoxy-3-phenylhexan-3-ol
1258208-68-2

6,6-diethoxy-3-phenylhexan-3-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: 1-phenyl-propan-1-one In tetrahydrofuran at -40 - 0℃; for 2.5h;
97%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin

5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin

5-[4-(oxy 3-propionaldehyde diethyl acetal)phenyl]-10,15,20-triphenyl-porphyrin

5-[4-(oxy 3-propionaldehyde diethyl acetal)phenyl]-10,15,20-triphenyl-porphyrin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h; Inert atmosphere;97%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

2-methyldiphenylsilyl-1,3-dithiane
135746-47-3

2-methyldiphenylsilyl-1,3-dithiane

<2-(3,3-Diethoxypropyl)-1,3-dithian-2-yl>methyldiphenylsilane
162318-00-5

<2-(3,3-Diethoxypropyl)-1,3-dithian-2-yl>methyldiphenylsilane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane 1.) -25 deg C, 2.5 h, 2.) -25 deg C, 4 h;96%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

phenyl isopropyl ketone
611-70-1

phenyl isopropyl ketone

6,6-diethoxy-2-methyl-3-phenylhexan-3-ol
1258208-69-3

6,6-diethoxy-2-methyl-3-phenylhexan-3-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: phenyl isopropyl ketone In tetrahydrofuran at -40 - 0℃; for 2.5h;
96%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

3-methyl-1-phenylbutan-1-one
582-62-7

3-methyl-1-phenylbutan-1-one

1,1-diethoxy-6-methyl-4-phenylheptan-4-ol
1258208-70-6

1,1-diethoxy-6-methyl-4-phenylheptan-4-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: 3-methyl-1-phenylbutan-1-one In tetrahydrofuran at -40 - 0℃; for 2.5h;
95%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4,4-diethoxy-1-(4-methoxyphenyl)butan-1-ol
1258208-39-7

4,4-diethoxy-1-(4-methoxyphenyl)butan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: 4-methoxy-benzaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
95%
sodium cyanide
773837-37-9

sodium cyanide

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

4,4-diethoxybutanenitrile
18381-45-8

4,4-diethoxybutanenitrile

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In dimethyl sulfoxide at 50℃; for 15h;94%
In dimethyl sulfoxide at 80℃; for 24h;86%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

β-naphthaldehyde
66-99-9

β-naphthaldehyde

4,4-diethoxy-1-(naphthalen-2-yl)butan-1-ol
1258208-41-1

4,4-diethoxy-1-(naphthalen-2-yl)butan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: β-naphthaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
94%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

benzaldehyde
100-52-7

benzaldehyde

4-hydroxy-4-phenylbutanal diethyl acetal
112084-43-2

4-hydroxy-4-phenylbutanal diethyl acetal

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: benzaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
92%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

lithium acetylide-ethylenediamine complex
1216963-74-4

lithium acetylide-ethylenediamine complex

4-pentynyl diethyl acetal
68654-84-2

4-pentynyl diethyl acetal

Conditions
ConditionsYield
In dimethyl sulfoxide at 15℃; for 3h;91%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine
17242-85-2

5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

(1'RS)-1-(3'-Chloro-1'-ethoxypropyl)-5-fluorouracil
133625-58-8

(1'RS)-1-(3'-Chloro-1'-ethoxypropyl)-5-fluorouracil

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -30℃;91%
O-methylresorcine
150-19-6

O-methylresorcine

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

3-m-methoxyphenoxypropionaldehyde diethyl acetal
153750-80-2

3-m-methoxyphenoxypropionaldehyde diethyl acetal

Conditions
ConditionsYield
With sodium hydroxide In water 1.) room temperature, 30 min, 2.) reflux, 15 h;91%
Stage #1: O-methylresorcine With sodium hydroxide In water for 0.5h;
Stage #2: 3-chloro-1,1-diethoxy-propane In water for 16h; Reflux;
47%
2,5-Dimethylphenol
95-87-4

2,5-Dimethylphenol

3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

3-(2,5-dimethylphenoxy)propanal diethylacetal
1025804-42-5

3-(2,5-dimethylphenoxy)propanal diethylacetal

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydroxide Heating;90%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

3-azidopropanal diethyl acetal
688317-69-3

3-azidopropanal diethyl acetal

Conditions
ConditionsYield
With sodium azide In dimethyl sulfoxide at 50℃; for 16h;90%
With sodium azide; potassium iodide In dimethyl sulfoxide at 20 - 90℃; Inert atmosphere;88%
With sodium azide In dimethyl sulfoxide at 50℃; for 16h;
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

4,4-diethoxy-1-(4-fluorophenyl)butan-1-ol
1258208-40-0

4,4-diethoxy-1-(4-fluorophenyl)butan-1-ol

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With magnesium; ethylene dibromide In tetrahydrofuran at 15 - 25℃;
Stage #2: 4-fluorobenzaldehyde In tetrahydrofuran at -40 - 0℃; for 2.5h;
90%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

p-hydroxybenzamide
619-57-8

p-hydroxybenzamide

4-(3,3-diethoxypropoxy)benzamide
1409760-30-0

4-(3,3-diethoxypropoxy)benzamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 18h;89%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

D,L-1,2,4-butanetriol
3068-00-6

D,L-1,2,4-butanetriol

cis-[2-(2-chloroethyl)-1,3-dioxan-4-yl]methanol

cis-[2-(2-chloroethyl)-1,3-dioxan-4-yl]methanol

Conditions
ConditionsYield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; Inert atmosphere; stereoselective reaction;89%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

phenylacetonitrile
140-29-4

phenylacetonitrile

α-(2,2-diethoxypropyl)benzyl cyanide
93722-30-6

α-(2,2-diethoxypropyl)benzyl cyanide

Conditions
ConditionsYield
Stage #1: phenylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: 3-chloro-1,1-diethoxy-propane In tetrahydrofuran at -78℃; Cooling;
87%
With sodium hydride In N,N-dimethyl-formamide at 70℃; for 2h;80%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate
51089-83-9

benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

Dibenzyl 5-(2-chloroethyl)-3,7-diethyl-2,8-dimethyldihydrodipyrrin-1,9-dicarboxylate
161690-40-0

Dibenzyl 5-(2-chloroethyl)-3,7-diethyl-2,8-dimethyldihydrodipyrrin-1,9-dicarboxylate

Conditions
ConditionsYield
With Montmorillonite K-10 clay; trifluoroacetic acid In dichloromethane87%
With Montmorillonite K-10 clay; trifluoroacetic acid In dichloromethane for 5h; Ambient temperature;87%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

6-cyano-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

6-cyano-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

6-(furan-2-yl)-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline

Conditions
ConditionsYield
Stage #1: 3-chloro-1,1-diethoxy-propane With iodine; magnesium In 2-methyltetrahydrofuran; ethylene dibromide at 60 - 65℃; for 5h;
Stage #2: 6-cyano-4-[3-chloro-4-(3-fluorobenzyloxy)phenyl]aminoquinazoline In 2-methyltetrahydrofuran; ethylene dibromide at 25 - 30℃; for 5h;
Stage #3: With hydrogenchloride In 2-methyltetrahydrofuran; water; ethylene dibromide at 50 - 55℃; for 4h;
86.2%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

2-o-Tolyl-pentanenitrile
145611-08-1

2-o-Tolyl-pentanenitrile

5,5-Diethoxy-2-propyl-2-o-tolyl-pentanenitrile
145611-11-6

5,5-Diethoxy-2-propyl-2-o-tolyl-pentanenitrile

Conditions
ConditionsYield
With sodium amide In toluene for 5h; Heating;85%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide
90312-02-0

N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide

C21H29NO5S

C21H29NO5S

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 80℃; Inert atmosphere;85%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol
23037-61-8

1-(3,4-dimethoxyphenyl)-2-methylpropan-2-ol

1-(2-chloroethyl)-3,3-dimethyl-6,7-dimethoxyisochroman
79842-27-6

1-(2-chloroethyl)-3,3-dimethyl-6,7-dimethoxyisochroman

Conditions
ConditionsYield
With tetrafluoroboric acid-diethyl ether complex In nitromethane for 1.3h;84%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol
70822-01-4

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

1-(2-chloroethyl)-4,4-dimethyl-6,7-dimethoxyisochroman
70822-39-8

1-(2-chloroethyl)-4,4-dimethyl-6,7-dimethoxyisochroman

Conditions
ConditionsYield
With tetrafluoroboric acid-diethyl ether complex In nitromethane at 22℃; for 3h;84%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

potassium phtalimide
1074-82-4

potassium phtalimide

N-(3,3-diethoxypropyl)phthalimide
2453-90-9

N-(3,3-diethoxypropyl)phthalimide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 145℃; for 5h;83%
3-chloro-1,1-diethoxy-propane
35573-93-4

3-chloro-1,1-diethoxy-propane

triethyl phosphite
122-52-1

triethyl phosphite

diethyl 3,3-diethoxypropylphosphonate
15110-17-5

diethyl 3,3-diethoxypropylphosphonate

Conditions
ConditionsYield
82%

35573-93-4Relevant articles and documents

A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Wang, Hui-Po,Lee, On,Fan, Chin-Tsai,Lee, Lain-Tze

, p. 569 - 572 (2007/10/02)

A new synthesis of antihyperlipoproteinemic agent 2,2-dimethyl-5-(2,5-dimethylphenoxy) pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β-lactone 6, prepared from cycloaddition of 3-(2,5-dimethylphenoxy) propanal with dimethylketene.The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industral scale of production.Key Words Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; Dimethylketene; cycloaddition; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-3-hydroxypentanoic acid β-lactone.

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