1026177-04-7

Basic information

• Product Name: [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester
• Synonyms: [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester
• CAS NO: 1026177-04-7
• Molecular Weight: 426.536
• Mol File: 1026177-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester(1026177-04-7)
• EPA Substance Registry System: [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester(1026177-04-7)

Safety Data

• Hazardous Substances Data: 1026177-04-7(Hazardous Substances Data)

Upstream product

• 190604-12-7 (7-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester 
• 190604-13-8 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester 
• 190604-11-6 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one 
• 22246-05-5 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinoline 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 190604-14-9 [7-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 

Downstream Products

• 190604-15-0 {7-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 1027514-28-8 [7-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 
• 1027994-02-0 {6-[2-(4-Carbamimidoyl-phenyl)-ethoxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 1026846-42-3 [7-(4-Methylsulfanylcarbonimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 

Relevant articles and documents

Non-peptide RGD surrogates which mimic a Gly-Asp β-turn: Potent antagonists of platelet glycoprotein IIb-IIIa

Cyclic heptapeptide 1, which contains an Arg-Gly-Asp sequence, has good affinity for the platelet receptor GPIIb-IIIa and was chosen for study by 1H NMR techniques. The key RGD sequence of this molecule was found to reside in a conformationally defined type II' Gly-Asp β-turn, and this information was used in the design of simple non-peptide RGD mimics. Disubstituted isoquinolones, bearing an acidic side chain at position 2 and a basic side chain at position 6, were prepared and were found to have modest affinity for GPIIb-IIIa. Systematic modification of the basic residue contained in these molecules yielded compounds with high affinity for GPIIb-IIIa.