190604-11-6

Basic information

• Product Name: 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one
• Synonyms: 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 190604-11-6
• Molecular Weight: 253.301
• Mol File: 190604-11-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one(190604-11-6)
• EPA Substance Registry System: 7-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one(190604-11-6)

Safety Data

• Hazardous Substances Data: 190604-11-6(Hazardous Substances Data)

Upstream product

• 38480-95-4 6-methoxy-1H-inden-1-one 
• 22246-05-5 7-hydroxy-3,4-dihydro-1-oxo-2(1H)-isoquinoline 
• 100-44-7 benzyl chloride 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 190604-15-0 {7-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 1026846-42-3 [7-(4-Methylsulfanylcarbonimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 
• 1027514-28-8 [7-(4-Carbamimidoyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 
• 1026177-04-7 [1-Oxo-7-(4-thiocarbamoyl-benzyloxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 
• 1027994-02-0 {6-[2-(4-Carbamimidoyl-phenyl)-ethoxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-acetic acid tert-butyl ester 
• 190604-14-9 [7-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester 
• 190604-12-7 (7-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid tert-butyl ester 

Relevant articles and documents

Synthesis and pharmacological evaluation of new 3,4-dihydroisoquinolin derivatives containing heterocycle as potential anticonvulsant agents

Two novel series of 3,4-dihydroisoquinolin with heterocycle derivatives (4a-t and 9a-e) were synthesized and evaluated for their anticonvulsant activity using maximal electroshock (MES) test and pentylenetetrazole (PTZ)-induced seizure test. All compounds were characterized by IR, 1H-NMR, 13C-NMR, and mass spectral data. Among them, 9-(exyloxy)-5,6-dihydro-[1,2,4]triazolo[3,4-a] isoquinolin-3(2H)-one (9a) showed significant anticonvulsant activity in MES tests with an ED50 value of 63.31 mg/kg and it showed wide margins of safety with protective index (PI > 7.9). It showed much higher anticonvulsant activity than that of valproate. It also demonstrated potent activity against PTZ-induced seizures. A docking study of compound 9a in the benzodiazepine (BZD)-binding site of γ-aminobutyric acidA (GABAA) receptor confirmed possible binding of compound 9a with the BZD receptors.