1026183-20-9Relevant articles and documents
Regioselective synthesis and estrogenicity of (±)-8-alkyl-5,7- dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins
Roelens, Frederik,Huvaere, Kevin,Dhooge, Willem,Van Cleemput, Marjan,Comhaire, Frank,De Keukeleire, Denis
, p. 1042 - 1051 (2005)
Nine new (±)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4- dihydrocoumarins have been synthesized from 2,4,6-trimethoxybenzaldehyde via a short, efficient, and regioselective pathway, together with the unsubstituted analogue (±)-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarin. The compounds were tested for estrogenic activity using a yeast-based estrogen screen. Weak estrogenicity was determined for seven members of the series.
