1026639-43-9

Basic information

• Product Name: [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester
• Synonyms: [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester
• CAS NO: 1026639-43-9
• Molecular Weight: 337.373
• Mol File: 1026639-43-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester(1026639-43-9)
• EPA Substance Registry System: [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester(1026639-43-9)

Safety Data

• Hazardous Substances Data: 1026639-43-9(Hazardous Substances Data)

Upstream product

• 4779-31-1 Z-Asp-OBn 
• 78385-26-9 3-bromomethyl-3-methyloxetane 
• 613264-81-6 (S)-2-Benzyloxycarbonylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propionic acid benzyl ester 

Downstream Products

• 1027834-41-8 (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol 

Relevant articles and documents

Manipulating L-aspartic and L-glutamic acids - Diastereoselective synthesis of enantiopure β-amino-γ-hydroxy acids and γ-amino-δ-hydroxy acids

Enantiopure (3S,4R)- and (3S,4S)-3-amino-4-hydroxyhexanoic acids and (4S,5R)- and (4S,5S)-4-amino-5-hydroxyheptanoic acid derivatives have been prepared by stereodivergent synthesis from L-aspartic and L-glutamic acids, respectively. The stereochemistry at the carbon atom attached to the amino group was determined from the starting material but the configuration at C-4 or C-5 is controlled by diastereoselective alkylation with diethylzinc or ethylmagnesium bromide. The protection of the carboxylic group as OBO orthoester improved the yields in the final products. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2003.