1027834-41-8

Basic information

• Product Name: (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol
• Synonyms: (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol
• CAS NO: 1027834-41-8
• Molecular Weight: 383.488
• Mol File: 1027834-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol(1027834-41-8)
• EPA Substance Registry System: (S)-2-Dibenzylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propan-1-ol(1027834-41-8)

Safety Data

• Hazardous Substances Data: 1027834-41-8(Hazardous Substances Data)

Upstream product

• 613264-80-5 (S)-2-Benzyloxycarbonylamino-succinic acid 1-benzyl ester 4-(3-methyl-oxetan-3-ylmethyl) ester 
• 613264-81-6 (S)-2-Benzyloxycarbonylamino-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-propionic acid benzyl ester 
• 1026639-43-9 [(S)-1-Hydroxymethyl-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester 
• 78385-26-9 3-bromomethyl-3-methyloxetane 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Manipulating L-aspartic and L-glutamic acids - Diastereoselective synthesis of enantiopure β-amino-γ-hydroxy acids and γ-amino-δ-hydroxy acids

Enantiopure (3S,4R)- and (3S,4S)-3-amino-4-hydroxyhexanoic acids and (4S,5R)- and (4S,5S)-4-amino-5-hydroxyheptanoic acid derivatives have been prepared by stereodivergent synthesis from L-aspartic and L-glutamic acids, respectively. The stereochemistry at the carbon atom attached to the amino group was determined from the starting material but the configuration at C-4 or C-5 is controlled by diastereoselective alkylation with diethylzinc or ethylmagnesium bromide. The protection of the carboxylic group as OBO orthoester improved the yields in the final products. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2003.