1026754-33-5

Basic information

• Product Name: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide
• Synonyms: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide
• CAS NO: 1026754-33-5
• Molecular Weight: 444.552
• Mol File: 1026754-33-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide(1026754-33-5)
• EPA Substance Registry System: N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide(1026754-33-5)

Safety Data

• Hazardous Substances Data: 1026754-33-5(Hazardous Substances Data)

Upstream product

• 1401355-78-9 4-[(3-carbethoxyamino)-propoxy]benzoylchloride 
• 1401355-77-8 N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide 
• 1401355-76-7 (5-nitro-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone 
• 1401355-75-6 (5-amino-2-butylbenzofuran-3-yl)-[4-(2-cyanoethoxy)phenyl]methanone 
• 1401355-74-5 N-[2-butyl-3-{4-[2-cyanoethoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide 
• 437652-07-8 N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 

Downstream Products

• 141626-36-0 dronedarone 

Relevant articles and documents

REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.

PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3-CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.