1401355-77-8

Basic information

• Product Name: N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide
• Synonyms: N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide
• CAS NO: 1401355-77-8
• Molecular Weight: 516.615
• Mol File: 1401355-77-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide(1401355-77-8)
• EPA Substance Registry System: N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide(1401355-77-8)

Safety Data

• Hazardous Substances Data: 1401355-77-8(Hazardous Substances Data)

Upstream product

• 437652-07-8 N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide 
• 1401355-78-9 4-[(3-carbethoxyamino)-propoxy]benzoylchloride 

Downstream Products

• 141626-36-0 dronedarone 
• 1026754-33-5 N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide 

Relevant articles and documents

PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3—CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.

PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3-CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.