102676-60-8

Basic information

• Product Name: Methyl 3-(1-Tritylimidazol-4-yl) Propionate
• Synonyms: 3-(1-Triphenylmethyl-1H-imidazol-4-yl)propionic Acid Methyl Ester;1-(Triphenylmethyl)-1H-imidazole-4-propanoic Acid Methyl Ester;methyl 3-(1-trityl-1H-imidazol-4-yl)propanoate;3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester
• CAS NO: 102676-60-8
• Molecular Formula: C₂₆H₂₄N₂O₂
• Molecular Weight: 396.48
• Product Categories: Aromatics Compounds;Aromatics;Heterocycles;Miscellaneous Reagents
• Mol File: 102676-60-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 140-142°C
• Boiling Point: 530.985°C at 760 mmHg
• Flash Point: 274.93°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: -20?C Freezer
• CAS DataBase Reference: Methyl 3-(1-Tritylimidazol-4-yl) Propionate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(1-Tritylimidazol-4-yl) Propionate(102676-60-8)
• EPA Substance Registry System: Methyl 3-(1-Tritylimidazol-4-yl) Propionate(102676-60-8)

Safety Data

• Hazardous Substances Data: 102676-60-8(Hazardous Substances Data)

Usage

Description

Methyl 3-(1-Tritylimidazol-4-yl) Propionate, with the CAS number 102676-60-8, is a white solid compound that is primarily utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
Methyl 3-(1-Tritylimidazol-4-yl) Propionate is used as a synthetic building block for the creation of more complex organic molecules. Its trityl-protected imidazole group provides a versatile handle for further functionalization and modification, making it a valuable intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 3-(1-Tritylimidazol-4-yl) Propionate is used as a key intermediate in the development of new drugs. Its unique chemical structure allows for the design and synthesis of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
Methyl 3-(1-Tritylimidazol-4-yl) Propionate is also used in academic and industrial research settings to study various aspects of organic chemistry, such as reaction mechanisms, stereochemistry, and the development of new synthetic methods.

InChI:InChI=1/C26H24N2O2/c1-30-25(29)18-17-24-19-28(20-27-24)26(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,19-20H,17-18H2,1H3

Upstream product

• 76-83-5 trityl chloride 
• 31434-93-2 methyl 3-(4-imidazolyl)propionate 
• 53958-94-4 3-(1H-imidazol-4-yl)propionic acid methyl ester hydrochloride 
• 138408-36-3 trans-1-trityl-4-imidazoleacrylic acid methyl ester 
• 54260-89-8 trans-4-imidazoleacrylic acid methyl ester hydrochloride 
• 3465-72-3 (E)-3-(1H-imidazol-4-yl)propenoic acid 
• 53958-93-3 3-(4-imidazolyl)propionic acid monohydrochloride 
• 70346-51-9 (E)-methyl 3-(1H-imidazol-4-yl)acrylate 
• 104-98-3 urocanic acid 
• 160073-02-9 methyl 3-(imidazol-4⁽⁵⁾-yl)-2-propenoate 
• 3465-72-3 urocanic Acid 

Downstream Products

• 102676-61-9 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde 
• 152030-49-4 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol 
• 199007-42-6 2-Benzyl-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester 
• 160446-35-5 3-(1H-1-triphenylmethylimidazol-4-yl)propanoic acid 
• 405551-80-6 N-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-(1-trityl-1H-imidazol-4-yl)-propionamide 
• 52237-35-1 3-(1H-imidazol-5-yl)propan-1-ol monohydrobromide 
• 220377-96-8 ethyl (2E)-5-(1-triphenylmethyl-1H-imidazol-4-yl)pent-2-enoate 
• 102676-68-6 ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pentanoate 
• 220377-99-1 5-(1-trityl-1H-imidazol-4-yl)pentan-1-ol 
• 637337-52-1 (R)-4-(1-methylethyl)-5,5-diphenyl-3-{3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoyl}oxazolidin-2-one 
• 637337-70-3 (S)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid 
• 847153-59-7 H-(S)-β²hHis(Tr)-OH 
• 847153-57-5 (S)-benzyl 2-(hydroxymethyl)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate 
• 847153-58-6 (S)-benzyl 2-(azidomethyl)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate 

Relevant articles and documents

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

1,(3,)5-substituted imidazoles, useful in the treatment of hypertension and methods for their preparation

The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for transdermal delivery. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing compounds and their use in methods of treating hypertension and cardiovascular diseases.

N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors

The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula I wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxycarbonyl or halogen, or (C1-3)alkyloxycarbonyl; or R1 is phenyl, optionally substituted with 1-3 substituents independently selected from (C1-3)alkyl, (C1-3)alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.