1026910-46-2

Basic information

• Product Name: 2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione
• CAS NO: 1026910-46-2
• Molecular Weight: 416.5
• Mol File: 1026910-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione(1026910-46-2)
• EPA Substance Registry System: 2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione(1026910-46-2)

Safety Data

• Hazardous Substances Data: 1026910-46-2(Hazardous Substances Data)

Upstream product

• 99-89-8 4-Isopropylphenol 
• 136918-14-4 phthalimide 
• 903886-70-4 5-bromo-2-(4-isopropylphenoxy)thiazole 
• 14396-89-5 2-(1-methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy) thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors

A structurally novel acetyl-CoA carboxylase (ACC) inhibitor is identified from high-throughput screening. A preliminary structure-activity relationship study led to the discovery of potent dual ACC1/ACC2 and ACC2 selective inhibitors against human recombinant ACC1 and ACC2. Selective ACC2 inhibitors exhibited IC50 1000-fold selectivity against ACC1. (S)-Enantiomer 9p exhibited high ACC2 activity and lowered muscle malonyl-CoA dose-dependently in acute rodent studies, whereas (R)-enantiomer 9o was weak and had no effect on the malonyl-CoA level.