14396-89-5

Basic information

• Product Name: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE
• Synonyms: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE;2-(1-Methylprop-2-ynyl)-1H-isoindole-1,3(2H)-dione;2-(1-Methylprop-2-ynyl)isoindole-1,3-dione;N-(1-Methyl-2-propynyl)phthalimide
• CAS NO: 14396-89-5
• Molecular Formula: C₁₂H₉NO₂
• Molecular Weight: 199.20536
• Mol File: 14396-89-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 107-109℃
• Boiling Point: 310℃
• Flash Point: 134℃
• Appearance: /
• Density: 1.285
• CAS DataBase Reference: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE(14396-89-5)
• EPA Substance Registry System: 2-(BUT-3-YN-2-YL)ISOINDOLINE-1,3-DIONE(14396-89-5)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 14396-89-5(Hazardous Substances Data)

Usage

Type of compound

heterocyclic

Core structure

isoindoline-1,3-dione

Substituent

but-3-yn-2-yl

Usage

organic synthesis and medicinal chemistry research

Value

valuable tool for drug and material development

Potential applications

pharmaceutical industry

Ongoing research

synthesis, characterization, and potential uses in various fields.

Upstream product

• 136918-14-4 phthalimide 
• 2028-63-9 but-3-yn-2-ol 
• 53487-52-8 1-methylprop-2-ynyl p-toluenesulfonate 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 777949-60-7 2-[1-methyl-3-(phenylseleno)prop-2-ynyl]-1H-isoindole-1,3(2H)dione 
• 1026910-46-2 2-{3-[2-(4-isopropyl-phenoxy)-thiazol-5-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione 
• 903886-66-8 2-{3-[2-(4-isopropoxyphenoxy)thiazol-5-yl]-1-methyl-prop-2-ynyl}isoindole-1,3-dione 
• 1035975-95-1 2-{3-[4-(4-isopropoxy-phenoxy)-phenyl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione 
• 904962-08-9 2-{1-methyl-3-[2-(4-phenoxyphenoxy)-1,3-thiazol-5-yl]prop-2-ynyl}-1H-isoindole-1,3(2H)-dione 
• 929118-50-3 2-(4-(2-(4-(cyclopropylmethoxy)phenoxy)thiazol-5-yl)but-3-yn-2-yl)isoindoline-1,3-dione 
• 929118-36-5 2-(1-(3-(2-(4-isopropoxyphenoxy)thiazol-5-yl)isoxazol-5-yl)ethyl)isoindoline-1,3-dione 
• 777949-85-6 Se-phenyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butaneselenoate 
• 904961-15-5 2-{3-[6-(4-phenoxy-phenoxy)-pyridin-3-yl]-1-methyl-prop-2-ynyl}-isoindole-1,3-dione 
• 946884-27-1 2-(1-{3-[4-(4-isopropoxyphenoxy)phenyl]isoxazol-5-yl}ethyl)-1H-isoindole-1,3(2H)-dione 
• 42105-26-0 (1-methylprop-2-yn-1-yl)amine hydrochloride 
• 1407998-90-6 2-[4-(4-methoxyphenyl)but-3-yn-2-yl]isoindoline-1,3-dione 
• 1407998-92-8 2-[4-(p-tolyl)but-3-yn-2-yl]isoindoline-1,3-dione 

Relevant articles and documents

An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes

Propargyl amines are versatile synthetic intermediates with numerous applications in the pharmaceutical industry. An attractive strategy for efficient preparation of these compounds is nitrene propargylic C(sp3)-H insertion. However, achieving this reacti

1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION

The present invention refers to compounds of formula (I). The present invention also relates to compounds of formula (I) for use as G Protein coupled Receptor 139 (GPR139) antagonists in methods of medical treatment of e.g. depression, Alzheimer's disease

Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process

The non-enzymatic kinetic resolution of diversely substituted primary propargylic amines is reported featuring a highly selective acetyl transfer using (1S,2S)-1 in conjunction with AliquatTM 336, affording the corresponding enantio-enriched N-