1026986-34-4Relevant articles and documents
Concise Synthesis of Furo[2,3- b ]indolines via [3,3]-Sigmatropic Rearrangement of N -Alkenyloxyindoles
Shevlin, Michael,Strotman, Neil A.,Anderson, Laura L.
supporting information, p. 197 - 201 (2020/09/21)
A concise new synthetic route to furo[2,3- b ]indolines has been developed by taking advantage of the reactivity of N -alkenyloxyindole intermediates. These compounds spontaneously undergo [3,3]-sigmatropic rearrangement followed by cyclization to form hemiaminals as single diastereomers. Tin-promoted N -hydroxyindole formation followed by conjugate addition to activated alkynes provides simple and modular access to a diverse array of N -alkenyloxyindoles and their corresponding furo[2,3- b ]indolines. Microscale high-throughput experimentation was used to facilitate investigation of the scope and tolerance of this transformation and related studies on the nucleophilic aromatic substitution and rearrangement of N -hydroxyindoles with halogenated arenes have also been evaluated.
Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2
Kimura,Watanabe,Matsui,Hayashi,Tanaka,Ohtsuka,Saeki,Kogushi,Kabayashi,Akasaka,Yamagishi,Saitou,Yamatsu
, p. 1641 - 1653 (2007/10/02)
In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl
