1027068-77-4 Usage
General Description
5-Hydroxy-4-azaindole-3-carbaldehyde, also known as 5-Hydroxy-4-aza-1H-indole-3-carbaldehyde, is a chemical compound with the molecular formula C9H7N2O2. It is a derivative of indole, containing a hydroxyl group and an aldehyde group attached to a pyridine ring. 5-Hydroxy-4-azaindole-3-carbaldehyde is a key intermediate in the synthesis of various pharmaceuticals and organic compounds. It is commonly used in the manufacture of pharmaceuticals, dyes, and other organic compounds. 5-Hydroxy-4-azaindole-3-carbaldehyde is an important building block in the synthesis of drugs and other active pharmaceutical ingredients, and it is widely utilized in the pharmaceutical and chemical industries for this purpose.
Check Digit Verification of cas no
The CAS Registry Mumber 1027068-77-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,7,0,6 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1027068-77:
(9*1)+(8*0)+(7*2)+(6*7)+(5*0)+(4*6)+(3*8)+(2*7)+(1*7)=134
134 % 10 = 4
So 1027068-77-4 is a valid CAS Registry Number.
1027068-77-4Relevant articles and documents
The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.
Buchheit,Gamse,Giger,Hoyer,Klein,Kloeppner,Pfannkuche,Mattes
, p. 2331 - 2338 (2007/10/02)
A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.
