17288-40-3

Basic information

• Product Name: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE
• Synonyms: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE;5-METHOXY-4-AZAINDOLE;5-Methoxypyrrolo[3,2-b]pyridine;5-Methoxy-4-azaindole,5-Methoxy-1H-pyrrolo[3,2-b]pyridine;1H-Pyrrolo[3,2-b]pyridine, 5-Methoxy-;5-Metho×y-4-azaindole,5-Metho×y-1H-pyrrolo[3,2-b]pyridine;5-Methoxy-1H-pyrrolo[3
• CAS NO: 17288-40-3
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Product Categories: Heterocycle-Pyridine series
• Mol File: 17288-40-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 115-116°C
• Boiling Point: 285℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.244
• Vapor Pressure: 0.00509mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 2-8°C
• PKA: 14.36±0.40(Predicted)
• CAS DataBase Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE(17288-40-3)
• EPA Substance Registry System: 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE(17288-40-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 17288-40-3(Hazardous Substances Data)

Usage

General Description

5-Methoxy-1H-pyrrolo[3,2-b]pyridine is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic compound with a pyrrolopyridine skeleton containing a methoxy group at the 5-position. 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE has potential pharmaceutical importance due to its ability to act as a ligand for various receptors and enzymes. It is also used as a building block in the synthesis of biologically active compounds. 5-Methoxy-1H-pyrrolo[3,2-b]pyridine is not found naturally in living organisms, but it is made synthetically for research and pharmaceutical purposes.

InChI:InChI=1/C8H8N2O/c1-11-8-3-2-6-7(10-8)4-5-9-6/h2-5,9H,1H3

Upstream product

• 111795-99-4 2-(6-methoxy-3-nitropyridin-2-yl)acetonitrile 
• 5467-69-6 6-methoxy-3-nitro-2-picoline 
• 5815-08-7 tert-Butoxybis(dimethylamino)methane 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 570386-39-9 2-Methoxy-5-Nitro-6-(2-Dimethylaminoethen-1-yl)pyridine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 152562-42-0 (5-methoxy-3-nitro-pyridin-2-yl)-acetonitrile 
• 22280-60-0 6-chloro-4-methyl-3-nitropyridine 
• 22280-62-2 6-methyl-5-nitro-2-pyridinamine 
• 28489-45-4 6-methyl-5-nitropyridin-2(1H)-one 

Downstream Products

• 17288-55-0 3-formyl-5-methoxy-1H-pyrrolo<3,2-b>pyridine 
• 438468-78-1 1-[3-(Benzyloxy)propyl]-5-methoxy-1H-pyrrolo[3,2-b]pyridine 
• 372077-49-1 1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridine 
• 677302-48-6 1-benzenesulfonyl-1,4-dihydro-5H-pyrrolo[3,2-b]pyridin-5-one 
• 737003-25-7 1-benzenesulfonyl-5-(4-bromobutoxy)-1H-pyrrolo[3,2-b]pyridine 
• 737003-26-8 1-benzenesulfonyl-5-(5-bromopentyloxy)-1H-pyrrolo[3,2-b]pyridine 
• 737003-27-9 1-benzenesulfonyl-5-(6-bromohexyloxy)-1H-pyrrolo[3,2-b]pyridine 
• 737003-31-5 1,4-bis[(1-benzenesulfonyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane 
• 737003-32-6 1,5-bis[(1-benzenesulfonyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]pentane 
• 737003-33-7 1,6-bis[(1-benzenesulfonyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]hexane 
• 1027068-77-4 5-oxo-4,5-dihydro-1H-pyrrolo<3,2-b>pyridine-3-carbaldehyde 
• 55556-41-7 5-methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 1175014-77-3 5-methoxy-1-phenyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.

3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES

The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

3-Amino-1-arylpropyl azaindoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.