1027942-57-9

Basic information

• Product Name: [1-(2-Fluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine
• CAS NO: 1027942-57-9
• Molecular Weight: 307.345
• Mol File: 1027942-57-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(2-Fluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(2-Fluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine(1027942-57-9)
• EPA Substance Registry System: [1-(2-Fluoro-4-methoxy-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine(1027942-57-9)

Safety Data

• Hazardous Substances Data: 1027942-57-9(Hazardous Substances Data)

Upstream product

• 5470-49-5 4-methanesulfonylphenylamine 
• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 104-96-1 4-methylsulfanylaniline 

Downstream Products

• 265113-59-5 5-(2-Fluoro-4-methoxyphenyl)-1-(4-methylsulfonylphenyl)imidazole(62 % yield) 

Relevant articles and documents

Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-Diarylimidazoles

The synthesis and the pharmacological activity of a series of 1,5-diarylimidazoles developed as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in human whole blood) and in vivo (carrageenan-induced paw edema, air-pouch, and hyperalgesia tests). Modification of all the positions of two regioisomeric imidazole cores led to the identification of 4-[4-chloro-5-(3-fluoro4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide (UR-8880, 51f) as the best candidate, which is now undergoing Phase I clinical trials.