5470-49-5

Basic information

• Product Name: 4-Methylsulfonylaniline
• Synonyms: -(Methylsulfonyl)aniline;Benzenamine, 4-(methylsulfonyl)-;niline, p-(methylsulfonyl)-;4-(METHYLSULPHONYL)ANILINE;4-(METHYLSULFONYL)ANILINE;4-METHYLSULFONYL-BENZENEAMINE;4-mesylaniline;BENZENEAMINE, 4-METHYLSULFONYL-
• CAS NO: 5470-49-5
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• EINECS: 226-803-8
• Mol File: 5470-49-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 243-245°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.44
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated)
• PKA: pK1:1.48(+1) (25°C)
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 4-Methylsulfonylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylsulfonylaniline(5470-49-5)
• EPA Substance Registry System: 4-Methylsulfonylaniline(5470-49-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 22-24/25
• HazardClass: 6.1
• Hazardous Substances Data: 5470-49-5(Hazardous Substances Data)

Usage

Uses

It is used as pharmaceutical intermediate. A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme.

InChI:InChI=1/C7H9NO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,8H2,1H3

Upstream product

• 2976-30-9 1-methanesulfonyl-4-nitrobenzene 
• 22821-80-3 N-(4-methanesulfonylphenyl)acetamide 
• 130188-79-3 N-(4-((2-oxo-2-phenylethyl)sulfonyl)phenyl)acetamide 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 3466-32-8 4-bromoohenyl methyl sulfone 
• 83048-63-9 4-(Aminophenyl)-sulfonylessigsaeure 
• 3926-62-3 sodium monochloroacetic acid 
• 74-88-4 methyl iodide 
• 473-27-8 4-(trifluoromethanesulfonyl)aniline 
• 75-16-1 methylmagnesium bromide 
• 104-96-1 4-methylsulfanylaniline 
• 20277-69-4 sodium methansulfinate 
• 106-40-1 4-bromo-aniline 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 17557-67-4 2-amino-6-(methylsulfonyl)benzothiazole 
• 64984-08-3 1-iodo-4-(methylsulfonyl)benzene 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 15863-56-6 1-isothiocyanato-4-methanesulfonyl-benzene 
• 177662-40-7 N-<4-(methylsulfonyl)phenyl>benzenecarboximidamide 
• 103854-70-2 N-(4-methanesulfonyl-phenyl)-N'-methyl-thiourea 
• 34392-62-6 sulfanilic acid-(4-methanesulfonyl-anilide) 
• 3622-29-5 2-Chlor-6-methylsulfonylbenzothiazol 
• 68105-58-8 (2,4-Dinitro-naphthalen-1-yl)-(4-methanesulfonyl-phenyl)-amine 
• 13791-91-8 2-(4-Chloro-2-methyl-phenoxy)-N-(4-methanesulfonyl-phenyl)-propionamide 
• 69733-00-2 (4'-methanesulfonyl)-N-phenylnitramine 
• 80866-96-2 2,6-dichloro-4-(methylsulfonyl)aniline 
• 29209-05-0 2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[e][1,2]thiazine-4-carboxylic acid 4-methanesulfonyl-anilide 
• 76663-19-9 2-(4-Methanesulfonyl-phenylamino)-N-(4-sulfamoyl-phenyl)-acetamide 

Relevant articles and documents

Method for catalytically oxidizing thioether to sulphone

The invention discloses a method for catalytically oxidizing thioether to sulphone. In this method, thioether is added to an ethanol solution. H2 O2 The nitrogen-nitrogen co-doped graphene catalyst is reacted at room temperature to obtain sulfone. The method is simple and convenient to operate, environment-friendly in reaction process, low in production cost, free of metal catalysts, free of secondary pollution, mild in reaction conditions, low in catalyst consumption, high and product yield and the like.

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple NiII salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the corresponding N-arylation product in an excellent yield.