15863-56-6

Basic information

• Product Name: Benzene, 1-isothiocyanato-4-(methylsulfonyl)-
• Synonyms: 4-mesylphenyl-isothiocyanate;4-methylsulfonylphenyl isothiocyanate;4-methylsulfonyl isothiocyanate;Benzene,1-isothiocyanato-4-(methylsulfonyl);1-isothiocyanato-4-(methylsulfonyl)benzene;4-methanesulfonyl-phenyl isothiocyanate;4-Methansulfonyl-phenylisothiocyanat;Isothiocyanato-4-methanesulfonylbenzene;1-isothiocyanato-4-methanesulfonylbenzene
• CAS NO: 15863-56-6
• Molecular Formula: C8H7NO2S2
• Molecular Weight: 213.281
• Mol File: 15863-56-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 1-isothiocyanato-4-(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-isothiocyanato-4-(methylsulfonyl)-(15863-56-6)
• EPA Substance Registry System: Benzene, 1-isothiocyanato-4-(methylsulfonyl)-(15863-56-6)

Safety Data

• Hazardous Substances Data: 15863-56-6(Hazardous Substances Data)

Upstream product

• 5470-49-5 4-methanesulfonylphenylamine 
• 594-42-3 chlorothio-trichloro-methane 
• 463-71-8 thiophosgene 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 177662-76-9 (4-methylsulfonyl)aniline hydrochloride 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 84783-67-5 (4-methanesulfonyl-phenyl)-thiourea 
• 1533424-12-2 N³-(4-methanesulfonylphenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 135805-98-0 N-(4-Mesylphenyl)-N'-4-(quinolin-2-yl-methoxy)phenyl-thiourea 

Relevant articles and documents

Synthesis of Isothiocyanates and Unsymmetrical Thioureas with the Bench-Stable Solid Reagent (Me4N)SCF3

A highly efficient, selective, and rapid transformation of primary amines and diamines to isothiocyanates and cyclic thioureas is disclosed. As opposed to established approaches that employ toxic or volatile electrophilic liquids and require reaction control (i.e., slow addition, cooling), this protocol utilizes the bench-stable, solid reagent (Me4N)SCF3 at room temperature. The method is characterized by operational simplicity, high speed, efficiency, high functional group tolerance, and late-stage applicability. The byproducts are solids, allowing isolation of the target compounds by filtration.

TRIAZOLE COMPOUNDS AS ANTIVIRALS

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.

8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS

Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and / or systemic lupus