1028026-73-4

Basic information

• Product Name: C₁₈H₂₃N₃O₇
• Synonyms: C₁₈H₂₃N₃O₇
• CAS NO: 1028026-73-4
• Molecular Weight: 393.397
• Mol File: 1028026-73-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₃N₃O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₃N₃O₇(1028026-73-4)
• EPA Substance Registry System: C₁₈H₂₃N₃O₇(1028026-73-4)

Safety Data

• Hazardous Substances Data: 1028026-73-4(Hazardous Substances Data)

Upstream product

• 100134-82-5 (cyano-dimethyl-methyl)carbamic acid benzyl ester 
• 518047-98-8 [1-(N'-hydroxycarbamimidoyl)-1-methyl-ethyl]carbamic acid benzyl ester 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 519028-33-2 {1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-1-methyl-ethyl}-carbamic acid benzyl ester 
• 518048-02-7 {1-[4-(4-fluoro-benzylcarbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl]-1-methyl-ethyl}carbamic acid benzyl ester 
• 519028-40-1 C₂₄H₂₅FN₄O₅ 
• 888504-27-6 2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester 
• 1159977-42-0 C₁₈H₂₁N₃O₆ 
• 1172131-65-5 C₂₉H₃₃FN₄O₆ 

Relevant articles and documents

Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium

A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key, highly functionalized hydroxypyrimidinone core 7. Utilizing this route 1 was prepared in nine linear chemical steps with 22% overall yield. A second-generation synthesis was subsequently developed that solved the key chemical, productivity, and environmental impact issues of the initial synthesis. Highlights of the new synthesis include a highly selective methylation, 3-4-fold higher productivity, and a 65% reduction of combined organic and aqueous waste produced. The efficient second-generation manufacturing route provides raltegravir potassium 1 in 35% overall yield.