519028-40-1

Basic information

• Product Name: C₂₄H₂₅FN₄O₅
• CAS NO: 519028-40-1
• Molecular Weight: 468.485
• Mol File: 519028-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₅FN₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₅FN₄O₅(519028-40-1)
• EPA Substance Registry System: C₂₄H₂₅FN₄O₅(519028-40-1)

Safety Data

• Hazardous Substances Data: 519028-40-1(Hazardous Substances Data)

Upstream product

• 140-75-0 para-fluorobenzylamine 
• 100134-82-5 (cyano-dimethyl-methyl)carbamic acid benzyl ester 
• 1064707-10-3 C₁₈H₂₃N₃O₇ 
• 1028026-73-4 C₁₈H₂₃N₃O₇ 
• 1028026-63-2 C₁₈H₂₃N₃O₇ 
• 518047-98-8 [1-(N'-hydroxycarbamimidoyl)-1-methyl-ethyl]carbamic acid benzyl ester 
• 519028-33-2 {1-[4-(4-fluoro-benzylcarbamoyl)-5,6-dihydroxy-pyrimidin-2-yl]-1-methyl-ethyl}-carbamic acid benzyl ester 
• 74-88-4 methyl iodide 

Relevant articles and documents

Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium

A manufacturing route for the synthesis of raltegravir potassium 1 was developed via a thermal rearrangement of amidoxime DMAD adducts 6 to construct the key, highly functionalized hydroxypyrimidinone core 7. Utilizing this route 1 was prepared in nine linear chemical steps with 22% overall yield. A second-generation synthesis was subsequently developed that solved the key chemical, productivity, and environmental impact issues of the initial synthesis. Highlights of the new synthesis include a highly selective methylation, 3-4-fold higher productivity, and a 65% reduction of combined organic and aqueous waste produced. The efficient second-generation manufacturing route provides raltegravir potassium 1 in 35% overall yield.