1028026-83-6

Basic information

• Product Name: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-
• CAS NO: 1028026-83-6
• Molecular Formula: C17H24N2O2
• Molecular Weight: 288.39
• Mol File: 1028026-83-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-(1028026-83-6)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 1,2-dihydro-5-methyl-4-[[4-(1-methylethoxy)phenyl]methyl]-1-(1-methylethyl)-(1028026-83-6)

Safety Data

• Hazardous Substances Data: 1028026-83-6(Hazardous Substances Data)

Upstream product

• 40141-12-6 1-(Chloromethyl)-4-(1-methylethoxy)benzene 
• 82657-71-4 (4-isopropoxyphenyl)methanol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 329044-14-6 1,2-dihydro-4-[(4-isopropoxyphenyl)methyl]-5-methyl-3H-pyrazol-3-one 
• 1171016-90-2 5-methyl-4-{[4-(propan-2-yloxy)phenyl]methyl}-1H-pyrazol-3-yl methanesulfonate 
• 75-26-3 isopropyl bromide 
• 18962-05-5 4-isopropoxybenzaldehyde 
• 1401335-14-5 methyl 2-[(4-isopropoxyphenyl)methyl]-3-oxobutanoate 
• 70629-60-6 isopropylhydrazine hydrochloride 

Downstream Products

• 1338796-70-5 5-methyl-1-(propan-2-yl)-4- [4-(propan-2-yloxy)benzyl]-1H-pyrazol-3-yl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 329045-45-6 [14C]-Remogliflozin 

Relevant articles and documents

An efficient and practical synthesis of remogliflozin etabonate, a potent inhibitor of low-affinity Na+-dependent glucose co-transporter (SGLT2)

A practical process for the preparation of remogliflozin etabonate, a prodrug of the selective low-affinity Na+-dependent glucose co-transporter (SGLT2) inhibitor, remogliflozin, is described. We established a chemoselective synthetic route to 1,2-dihydro-4-[(4-isopropoxyphenyl)methyl]-1-isopropyl-5-methyl-3H-pyrazol-3-one and an efficient O-glycosylation of this compound with 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide. This synthetic process provided remogliflozin etabonate in a 39% overall yield from commercially available 4-isopropoxybenzaldehyde.

Method of manufacturing benzylsuccinic Pyrazolecarboxylic deriv. and its intermediate

A production intermediate of a glucopyranosyloxypyrazole derivative which is represented by general formula (E) (wherein R3 and R4 are as defined below) and is useful as a therapeutic agent for diabetes or the like, and a method for producing a benzylpyrazole derivative, said method being indistrially more advantageous than conventional methods for producing a benzylpyrazole derivative, can be provided by causing a reaction of a compound represented by general formula (D) (wherein each of R1 and R2 represents a C1-6 alkyl group or the like; R3 represents a halogen atom, a C1-6 alkoxy group or the like; and R4 represents a hydrogen atom, a halogen atom, a C1-6 alkoxy group or the like).