103057-61-0

Basic information

• Product Name: Flomoxef sodium intermediate
• CAS NO: 103057-61-0
• Molecular Formula: C₂₅H₂₆N₆O₆S
• Molecular Weight: 538.5780
• Mol File: 103057-61-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Flomoxef sodium intermediate(CAS DataBase Reference)
• NIST Chemistry Reference: Flomoxef sodium intermediate(103057-61-0)
• EPA Substance Registry System: Flomoxef sodium intermediate(103057-61-0)

Safety Data

• Hazardous Substances Data: 103057-61-0(Hazardous Substances Data)

Usage

General Description

Flomoxef sodium intermediate is a chemical compound used in the synthesis of the antibiotic flomoxef sodium. It is an intermediate in the process of converting 7-ADCA (7-aminocephalosporanic acid) into the final product, flomoxef sodium. Flomoxef sodium intermediate plays a crucial role in the production of the antibiotic, which is used to treat a wide range of bacterial infections. Flomoxef sodium intermediate is an important component in the pharmaceutical industry for the production of antibiotics and contributes to the overall availability and efficacy of flomoxef sodium for medical use.

Upstream product

• 68314-38-5 (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 949587-46-6 benzhydryl 7β-[2-(difluoromethylthio)acetamido]-7α-methoxy-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate 
• 99665-00-6 flomoxef 

Relevant articles and documents

A method for the preparation of fluorine oxygen spore sodium

The invention belongs to a new flomoxef sodium preparation method, and particularly relates to a preparation method of flomoxef sodium. The method comprises the steps of: enabling a compound (I) to react with methyl alcohol to generate a compound (II) under the catalysis of ceric ammonium nitrate, next connecting with a tetrazole side chain to obtain a compound (III), removing an amino protection group and a hydroxyl protection group under enzymolysis to obtain a compound (IV), reacting with an intermediate of difluromethylation mercaptoacetic acid active ester to obtain a compound (V), removing the hydroxyl protection group under the effect of trifluoroacetic acid to obtain a compound (VI), and finally obtaining the flomoxef sodium (VII) through a formed sodium salt reaction. The reaction route is as follows. The method provided by the invention has the following advantages that the reaction operation is simple, convenient and reliable, the reaction route is short, the aims of going green and environmental protection, and high productivity are realized, the after-treatment is easy and high-purity flomoxef sodium is obtained.