949587-46-6

Basic information

• Product Name: FloMoxef Benzhydryl Ester
• Synonyms: FloMoxef Benzhydryl Ester
• CAS NO: 949587-46-6
• Molecular Formula: C28H28F2N6O7S2
• Molecular Weight: 662.6847264
• Product Categories: Heterocycles, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 949587-46-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• Solubility: DCM, Ethyl Acetate, Methanol
• PKA: 11.28±0.60(Predicted)
• CAS DataBase Reference: FloMoxef Benzhydryl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: FloMoxef Benzhydryl Ester(949587-46-6)
• EPA Substance Registry System: FloMoxef Benzhydryl Ester(949587-46-6)

Safety Data

• Hazardous Substances Data: 949587-46-6(Hazardous Substances Data)

Usage

Uses

Flomoxef Benzhydryl Ester is an intermediate in the synthesis of Flomoxef (F401850), an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

Upstream product

• 103057-61-0 benzhydryl 7β-amino-7α-methoxy-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylate 
• 83494-33-1 difluoromethylthioacetyl chloride 
• 103057-61-0 (6R,7R)-7-(amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid diphenylmethyl ester 
• 68314-38-5 (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 1239856-87-1 flomoxef acid 
• 99665-00-6 flomoxef 
• 99665-00-6 flomoxef 

Relevant articles and documents

A method for the preparation of fluorine oxygen spore sodium

The invention belongs to a new flomoxef sodium preparation method, and particularly relates to a preparation method of flomoxef sodium. The method comprises the steps of: enabling a compound (I) to react with methyl alcohol to generate a compound (II) under the catalysis of ceric ammonium nitrate, next connecting with a tetrazole side chain to obtain a compound (III), removing an amino protection group and a hydroxyl protection group under enzymolysis to obtain a compound (IV), reacting with an intermediate of difluromethylation mercaptoacetic acid active ester to obtain a compound (V), removing the hydroxyl protection group under the effect of trifluoroacetic acid to obtain a compound (VI), and finally obtaining the flomoxef sodium (VII) through a formed sodium salt reaction. The reaction route is as follows. The method provided by the invention has the following advantages that the reaction operation is simple, convenient and reliable, the reaction route is short, the aims of going green and environmental protection, and high productivity are realized, the after-treatment is easy and high-purity flomoxef sodium is obtained.